Construction of 2D Antimony(III) Selenide Nanosheets for Highly Efficient Photonic Cancer Theranostics

doi:10.1021/acsami.9b02104

	Construction of 2D Antimony(III) Selenide Nanosheets for Highly Efficient Photonic Cancer Theranostics
	Zhou, Yadan; Feng, Wei; Qian, Xiaoqin; Yu, Luodan; Han, Xiuguo; Fan, Gonglin; Chen, Yu; Zhu, Jiang
刊名	ACS APPLIED MATERIALS & INTERFACES
	2019-06-05
卷号	11 期号:22 页码:19712
关键词	two-dimensional antimony(III) selenide nanosheets photothermal therapy cancer nanomedicine
ISSN号	1944-8244
DOI	10.1021/acsami.9b02104
文献子类	Article
英文摘要	Photonic cancer hyperthermia has been considered to be one of the most representative noninvasive cancer treatments with high therapeutic efficiency and biosafety. However, it still remains a crucial challenge to develop efficient photothermal nanoagents with satisfactory photothermal performance and biocompatibility, among which two-dimensional (2D) ultrathin nanosheets have recently been regarded as the promising multifunctional theranostic agents for photothermal tumor ablation. In this work, we report, for the first time, on the construction of a novel kind of photothermal agents based on the intriguing 2D antimony(III) selenide (Sb2Se3) nanosheets for highly efficient photoacoustic imaging-guided photonic cancer hyperthermia by near-infrared (NIR) laser activation. These Sb2Se3 nanosheets were easily fabricated by a novel but efficiently combined liquid nitrogen pretreatment and freezing-thawing approach, which were featured with high photothermal-conversion capability (extinction coefficient: 33.2 L g(-1) cm(-1); photothermal-conversion efficiency: 30.78%). The further surface engineering of these Sb2Se3 ultrathin nanosheets with poly(vinyl pyrrolidone) (PVP) substantially improved the biocompatibility of the nanosheets and their stability in physiological environments, guaranteeing the feasibility in photonic antitumor applications. Importantly, 2D Sb2Se3 PVP nanosheets have been certificated to efficiently eradicate the tumors by NIR-triggered photonic tumor hyperthermia. Especially, the biosafety in vitro and in vivo of these Sb2Se3 ultrathin nanosheets has been evaluated and demonstrated. This work meaningfully expands the biomedical applications of 2D bionanoplatforms with a planar topology through probing into new members (Sb2Se3 in this work) of 2D biomaterials with unique intrinsic physiochemical property and biological effect.
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27060]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Zhou, Yadan,Feng, Wei,Qian, Xiaoqin,et al. Construction of 2D Antimony(III) Selenide Nanosheets for Highly Efficient Photonic Cancer Theranostics[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(22):19712.
APA	Zhou, Yadan.,Feng, Wei.,Qian, Xiaoqin.,Yu, Luodan.,Han, Xiuguo.,...&Zhu, Jiang.(2019).Construction of 2D Antimony(III) Selenide Nanosheets for Highly Efficient Photonic Cancer Theranostics.ACS APPLIED MATERIALS & INTERFACES,11(22),19712.
MLA	Zhou, Yadan,et al."Construction of 2D Antimony(III) Selenide Nanosheets for Highly Efficient Photonic Cancer Theranostics".ACS APPLIED MATERIALS & INTERFACES 11.22(2019):19712.