Nano-Structure Designing Promotion Osseointegration of Hydroxyapatite Coated Ti-6Al-4V Alloy Implants in Diabetic Model

doi:10.1166/jbn.2019.2812

	Nano-Structure Designing Promotion Osseointegration of Hydroxyapatite Coated Ti-6Al-4V Alloy Implants in Diabetic Model
	Hu, Zhekai; Wang, Xiuhui; Xia, Wei; Wang, Zongliang; Zhang, Peibiao; Xia, Lunguo; Lin, Kaili; Zhu, Min
刊名	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
	2019-08-01
卷号	15 期号:8 页码:1701
关键词	Nano-Structure Designing Hydroxyapatite Coating Osseointegration Diabetes Mellitus
ISSN号	1550-7033
DOI	10.1166/jbn.2019.2812
文献子类	Article
英文摘要	Mammalian diabetes mellitus which contains altered microenvironment always impairs diverse cellular processes such as osteogenesis, angiogenesis and tissue regeneration via different mechanisms. For researches in materials science, modifying the ability of osteogenesis and angiogenesis in dental implants shows its significant importance. Nano-structure designing is considered as a facile strategy to improve the surface bioactivity of the implants. In this study, the nanorod-structured hydroxyapatite (HA) coatings on Ti-6Al-4V implants were facilely designed by the combination of plasma-spraying and hydrothermal treatment via varying reaction media. Intriguingly, hydrothermal treatment eliminated the glassy phase and impurity phases of HA coatings, and nanorod-structured surface was successfully constructed under hydrothermal treatment in Na3PO4 solution. Additionally, the HA coatings with nanorod-structured surface effectively promoted the adhesion and proliferation and further enhanced osteogenic differentiation of DM-rBMSCs in vitro, Moreover, the osseointegration of Ti-6Al-4V implants with nanorod-structured HA coating was also enhanced in diabetes mellitus rabbit model in vivo. Therefore, the nano-structured surface modification of HA coating on Ti-6Al-4V implants could target pathological bone loss via strengthening osteogenesis and angiogenesis and further potentially used as a therapeutic coating to promote diabetic osteointegration.
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/26943]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Hu, Zhekai,Wang, Xiuhui,Xia, Wei,et al. Nano-Structure Designing Promotion Osseointegration of Hydroxyapatite Coated Ti-6Al-4V Alloy Implants in Diabetic Model[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2019,15(8):1701.
APA	Hu, Zhekai.,Wang, Xiuhui.,Xia, Wei.,Wang, Zongliang.,Zhang, Peibiao.,...&Zhu, Min.(2019).Nano-Structure Designing Promotion Osseointegration of Hydroxyapatite Coated Ti-6Al-4V Alloy Implants in Diabetic Model.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,15(8),1701.
MLA	Hu, Zhekai,et al."Nano-Structure Designing Promotion Osseointegration of Hydroxyapatite Coated Ti-6Al-4V Alloy Implants in Diabetic Model".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 15.8(2019):1701.