LGE-CMR-derived texture features reflect poor prognosis in hypertrophic cardiomyopathy patients with systolic dysfunction: preliminary results

doi:10.1007/s00330-018-5391-5

	LGE-CMR-derived texture features reflect poor prognosis in hypertrophic cardiomyopathy patients with systolic dysfunction: preliminary results
	Cheng, Sainan 1,2; Fang, Mengjie3,4 ; Cui, Chen 1,2; Chen, Xiuyu 1,2; Yin, Gang 1,2; Prasad, Sanjay K.5; Dong, Di3,4 ; Tian, Jie3,4 ; Zhao, Shihua 1,2
刊名	EUROPEAN RADIOLOGY
	2018-11-01
卷号	28 期号:11 页码:4615-4624
关键词	Hypertrophic cardiomyopathy Cardiac magnetic resonance Late gadolinium enhancement Texture features Event-free survival
ISSN号	0938-7994
DOI	10.1007/s00330-018-5391-5
通讯作者	Dong, Di(di.dong@ia.ac.cn) ; Zhao, Shihua(cjrzhaoshihua2009@163.com)
英文摘要	Objectives To evaluate the prognostic value of texture features based on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) images in hypertrophic cardiomyopathy (HCM) patients with systolic dysfunction. Methods 67 HCM patients with systolic dysfunction (41 male and 26 female, mean age +/- standard deviation, 46.20 years +/- 13.38) were enrolled. All patients underwent 1.5 T CMR cine and LGE imaging. Texture features were extracted from LGE images. Cox proportional hazard analysis and Kaplan-Meier analysis were used to determine the association of texture features and traditional parameters with event free survival. Results Family history (hazard ratio [HR]=2.558, 95 % confidence interval [CI]=1.060-6.180), NYHA III-IV (HR=5.627, CI=1.652-19.173), left ventricular ejection fraction (HR=0.945, CI=0.902-0.991), left ventricular end-diastolic volume index (HR=1.006, CI=1.000-1.012), LGE extent (HR=1.911, CI=1.348-2.709) and three texture parameters [X0_H_skewness (HR=0.783, CI=0.691-0.889), X0_GLCM_cluster_tendency (HR=0.735, CI=0.616-0.877) and X0_GLRLM_energy (HR=1.344, CI=1.173-1.540)] were significantly associated with event free survival in univariate analysis (p<0.05). The HR of LGE extent (HR=1.548 [CI=1.046-2.293], 1.650 [CI=1.122-2.428] and 1.586 [CI=1.044-2.409] per 10 % increase, p<0.05) remained significant when adjusted by one of the three texture features. Conclusion Increased LGE heterogeneity (higher X0_GLRLM_energy, lower X0_H_skewness and lower X0_GLCM_cluster_tendency) was associated with adverse events in HCM patients with systolic dysfunction. Key Points Textural analysis from CMR can be applied in HCM. Texture features derived from LGE images can capture fibrosis heterogeneity. CMR texture analysis provides prognostic information in HCM patients.
资助项目	major international (regional) joint research project of National Science Foundation of China[81620108015] ; Capital Characteristic and Clinical Application Research Fund from the Beijing Municipal Commission of Science and Technology[Z161100000516110] ; National Natural Science Foundation of China[81771924] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81501616] ; National Natural Science Foundation of China[81301346] ; National Natural Science Foundation of China[81501549] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81671851] ; Science and Technology Service Network Initiative of the Chinese Academy of Sciences[KFJ-SW-STS-160] ; Key Research Program of the Chinese Academy of Sciences[KGZD-EW-T03] ; Instrument Developing Project[YZ201502] ; Strategic Priority Research Program (B) of the CAS[XDB02060010] ; Beijing Municipal Science and Technology Commission[Z161100002616022] ; Youth Innovation Promotion Association CAS
WOS关键词	LATE GADOLINIUM ENHANCEMENT ; MAGNETIC-RESONANCE ; CANCER HETEROGENEITY ; MYOCARDIAL FIBROSIS ; CLINICAL PROFILE ; SUDDEN-DEATH ; TASK-FORCE ; SURVIVAL ; OUTCOMES ; RISK
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000446542300016
资助机构	major international (regional) joint research project of National Science Foundation of China ; Capital Characteristic and Clinical Application Research Fund from the Beijing Municipal Commission of Science and Technology ; National Natural Science Foundation of China ; Science and Technology Service Network Initiative of the Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Instrument Developing Project ; Strategic Priority Research Program (B) of the CAS ; Beijing Municipal Science and Technology Commission ; Youth Innovation Promotion Association CAS
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/28130]
专题	中国科学院自动化研究所
通讯作者	Dong, Di; Zhao, Shihua
作者单位	1.Chinese Acad Med Sci, Dept Cardiac MR, Natl Ctr Cardiovasc Dis China, Fuwai Hosp, 167 Beilishi Rd, Beijing 100037, Peoples R China 2.Peking Union Med Coll, Fuwai Hosp, 167 Beilishi Rd, Beijing 100037, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, 95 East Zhongguancun Rd, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Royal Brompton Hosp, Cardiovasc Magnet Resonance Unit, NIHR Biomed Res Unit, Sydney St, London SW3 6NP, England
推荐引用方式 GB/T 7714	Cheng, Sainan,Fang, Mengjie,Cui, Chen,et al. LGE-CMR-derived texture features reflect poor prognosis in hypertrophic cardiomyopathy patients with systolic dysfunction: preliminary results[J]. EUROPEAN RADIOLOGY,2018,28(11):4615-4624.
APA	Cheng, Sainan.,Fang, Mengjie.,Cui, Chen.,Chen, Xiuyu.,Yin, Gang.,...&Zhao, Shihua.(2018).LGE-CMR-derived texture features reflect poor prognosis in hypertrophic cardiomyopathy patients with systolic dysfunction: preliminary results.EUROPEAN RADIOLOGY,28(11),4615-4624.
MLA	Cheng, Sainan,et al."LGE-CMR-derived texture features reflect poor prognosis in hypertrophic cardiomyopathy patients with systolic dysfunction: preliminary results".EUROPEAN RADIOLOGY 28.11(2018):4615-4624.