Selenium Stimulates Cadmium Detoxification in Caenorhabditis elegans through Thiols-Mediated Nanoparticles Formation and Secretion

doi:10.1021/acs.est.8b04200

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Selenium Stimulates Cadmium Detoxification in Caenorhabditis elegans through Thiols-Mediated Nanoparticles Formation and Secretion
	Li, LL ; Cui, YH ; Lu, LY ; Liu, YL ; Zhu, CJ ; Tian, LJ ; Li, WW ; Zhang, X ; Cheng, H ; Ma, JY
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2019
卷号	53 期号:5 页码:2344—2352
关键词	IN-VIVO SYNTHESIS QUANTUM DOTS RAMAN-SCATTERING TOXICITY COORDINATION NANOCRYSTALS GLUTATHIONE RESPONSES GENETICS CDSE
ISSN号	0013-936X
DOI	10.1021/acs.est.8b04200
文献子类	期刊论文
英文摘要	Antagonism between heavy metal and selenium (Se) could significantly affect their biotoxicity, but little is known about the mechanisms underlying such microbial-mediated antagonistic processes as well as the formed products. In this work, we examined the cadmium (Cd)Se interactions and their fates in Caenorhabditis elegans through in vivo and in vitro analysis and elucidated the machinery of Se-stimulated Cd detoxification. Although the Se introduction induced up to 3-fold higher bioaccumulation of Cd in C. elegans than the Cd-only group, the nematode viability remained at a similar level to the Cd-only group. The relatively lower level of reactive oxygen species in the Se & Cd group confirms a significantly enhanced Cd detoxification by Se. The CdSe interaction, mediated by multiple thiols, including glutathione and phytochelatin, resulted in the formation of less toxic cadmium selenide (CdSe)/cadmium sulfide (CdS) nanoparticles. The CdSe/CdS nanoparticles were mainly distributed in the pharynx and intestine of the nematodes, and continuously excreted from the body, which also benefitted the C. elegans survival. Our findings shed new light on the microbial-mediated CdSe interactions and may facilitate an improved understanding and control of Cd biotoxicity in complicated coexposure environments.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31808]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Univ Sci & Technol China, Dept Appl Chem, CAS Key Lab Urban Pollutant Convers, Hefei 230026, Anhui, Peoples R China; 2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China
推荐引用方式 GB/T 7714	Li, LL,Cui, YH,Lu, LY,et al. Selenium Stimulates Cadmium Detoxification in Caenorhabditis elegans through Thiols-Mediated Nanoparticles Formation and Secretion[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2019,53(5):2344—2352.
APA	Li, LL.,Cui, YH.,Lu, LY.,Liu, YL.,Zhu, CJ.,...&Yu, HQ.(2019).Selenium Stimulates Cadmium Detoxification in Caenorhabditis elegans through Thiols-Mediated Nanoparticles Formation and Secretion.ENVIRONMENTAL SCIENCE & TECHNOLOGY,53(5),2344—2352.
MLA	Li, LL,et al."Selenium Stimulates Cadmium Detoxification in Caenorhabditis elegans through Thiols-Mediated Nanoparticles Formation and Secretion".ENVIRONMENTAL SCIENCE & TECHNOLOGY 53.5(2019):2344—2352.