Luminescent Biofunctional Collagen Mimetic Nanofibers

doi:10.1021/acsomega.9b00740

	Luminescent Biofunctional Collagen Mimetic Nanofibers
	Sun, Xiuxia 2; He, Manman 2; Wang, Lang 2; Luo, Liting 1; Wang, Jie 1; Xiao, Jianxi 2
刊名	ACS OMEGA
	2019-10-08
卷号	4 期号:15 页码:16270-16279
ISSN号	2470-1343
DOI	10.1021/acsomega.9b00740
英文摘要	Collagen has long been one of the top targets for biomimetic design due to its superior structural and functional properties. Significant progress has been achieved to construct self-assembling peptides to mimic the fibrous nanostructure of native collagen, while it is still very demanding to fabricate peptide assemblies that can recapitulate both structural and biofunctional features of collagen. Herein, collagen-like peptides have been synthesized to contain negatively charged amino acids as the binding groups of lanthanide ions and the integrin-binding motif GFOGER. The simultaneous inclusion of negatively charged amino acids in the middle as well as at both terminals drives the peptides to self-assemble to form well-ordered nanofibers with distinct periodic banding patterns specifically mediated by lanthanide ions. The aggregation tendency and the morphology of the final assembled materials for the peptides are modulated in a pH-cooperative manner, which well mimics the pH-dependent fibrillogenesis of Type I collagen. The utilization of lanthanide ions in the system not only offers a convenient external stimulus but also functionalizes assembled materials with excellent luminescent features. Most notably, the lanthanide-triggered peptide assembled nanomaterials possess good cell adhesion properties, which resemble the biological function of collagen. This peptide-Ln(3+) system provides a facile and potent strategy to generate nanofibers that mimic both the structural and functional properties of natural collagen. These novel pH-responsive, luminescent, and biofunctional collagen mimetic nanofibers open fascinating opportunities in the development of improved functional biomaterials in tissue engineering, drug delivery, and medical diagnostics.
资助项目	National Natural Science Foundation of China[21775059] ; Fundamental Research Funds for the Central Universities[lzujbky-2018-78] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[Y6Y0021004]
WOS关键词	TRIPLE-HELIX ; MOLECULAR-STRUCTURE ; IN-VITRO ; PEPTIDE ; DESIGN ; FIBRILLOGENESIS ; NANOSHEETS ; INTEGRINS ; SCAFFOLD ; PH
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000490421100002
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/21456]
专题	中国科学院武汉物理与数学研究所
通讯作者	Xiao, Jianxi
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China 2.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Sun, Xiuxia,He, Manman,Wang, Lang,et al. Luminescent Biofunctional Collagen Mimetic Nanofibers[J]. ACS OMEGA,2019,4(15):16270-16279.
APA	Sun, Xiuxia,He, Manman,Wang, Lang,Luo, Liting,Wang, Jie,&Xiao, Jianxi.(2019).Luminescent Biofunctional Collagen Mimetic Nanofibers.ACS OMEGA,4(15),16270-16279.
MLA	Sun, Xiuxia,et al."Luminescent Biofunctional Collagen Mimetic Nanofibers".ACS OMEGA 4.15(2019):16270-16279.