A Versatile Theranostic Nanoemulsion for Architecture-Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

doi:10.1002/adma.201806444

	A Versatile Theranostic Nanoemulsion for Architecture-Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy
	Zhang, Yifan 1; Bo, Shaowei 3; Feng, Tao 1; Qin, Xialing 1; Wan, Yilin 1; Jiang, Shanshan 1; Li, Chunxiao 1; Lin, Jing 1; Wang, Tianfu 1; Zhou, Xin 2
刊名	ADVANCED MATERIALS
	2019-05-01
卷号	31 期号:21 页码:10
关键词	BODIPY amphiphiles multimodal imaging nanoemulsion perfluorocarbon photodynamic theranostics
ISSN号	0935-9648
DOI	10.1002/adma.201806444
英文摘要	To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate the preparation process. These issues would be of less concern if the nanocarrier itself has most of the theranostic functions. In this work, a poly(ethylene glycol)-boron dipyrromethene amphiphile (PEG-F-54-BODIPY) with 54 fluorine-19 (F-19) is synthesized and employed to emulsify perfluorohexane (PFH) into a theranostic nanoemulsion (PFH@PEG-F-54-BODIPY). The as-prepared PFH@PEG-F-54-BODIPY can perform architecture-dependent fluorescence/photoacoustic/F-19 magnetic resonance multimodal imaging, providing more information about the in vivo structure evolution of nanomedicine. Importantly, this nanoemulsion significantly enhances the therapeutic effect of BODIPY through both the high oxygen dissolving capability and less self-quenching of BODIPY molecules. More interestingly, PFH@PEG-F-54-BODIPY shows high level of tumor accumulation and long tumor retention time, allowing a repeated light irradiation after a single-dose intravenous injection. The all-in-one photodynamic theranostic nanoemulsion has simple composition, remarkable theranostic efficacy, and novel treatment pattern, and thus presents an intriguing avenue to developing clinically translatable theranostic agents.
资助项目	Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China[161032] ; Basic Research Program of Shenzhen[JCYJ20170412111100742] ; China Postdoctoral Science Foundation[2018M633138] ; National Natural Science Foundation of China[51573096] ; National Natural Science Foundation of China[31771036] ; National Natural Science Foundation of China[51703132] ; National Natural Science Foundation of China[21572168] ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project[2018B030308003] ; National Key Research and Development Program of China[2016YFC1304704]
WOS关键词	BODIPY DYES ; CANCER ; HYPOXIA ; NANOPARTICLES ; NANOMATERIALS ; NANOCARRIERS ; TOXICITY ; DELIVERY ; ALBUMIN ; DESIGN
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000474801000004
资助机构	Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Basic Research Program of Shenzhen ; Basic Research Program of Shenzhen ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Basic Research Program of Shenzhen ; Basic Research Program of Shenzhen ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Basic Research Program of Shenzhen ; Basic Research Program of Shenzhen ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Basic Research Program of Shenzhen ; Basic Research Program of Shenzhen ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; National Key Research and Development Program of China ; National Key Research and Development Program of China
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/14574]
专题	中国科学院武汉物理与数学研究所
通讯作者	Jiang, Zhong-Xing; Huang, Peng
作者单位	1.Shenzhen Univ, Guangdong Key Lab Biomed Measurements & Ultrasoun, Lab Evolutionary Theranost, Sch Biomed Engn,Hlth Sci Ctr, Shenzhen 518060, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Wuhan Univ, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yifan,Bo, Shaowei,Feng, Tao,et al. A Versatile Theranostic Nanoemulsion for Architecture-Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy[J]. ADVANCED MATERIALS,2019,31(21):10.
APA	Zhang, Yifan.,Bo, Shaowei.,Feng, Tao.,Qin, Xialing.,Wan, Yilin.,...&Huang, Peng.(2019).A Versatile Theranostic Nanoemulsion for Architecture-Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy.ADVANCED MATERIALS,31(21),10.
MLA	Zhang, Yifan,et al."A Versatile Theranostic Nanoemulsion for Architecture-Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy".ADVANCED MATERIALS 31.21(2019):10.