Total Synthesis of (+/-)-Cochlearol A

doi:10.1021/acs.orglett.9b02391

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Total Synthesis of (+/-)-Cochlearol A
	Zhang, Da-Wei 1,4; Xu, Wen-Dan 1,4; Fan, Hui-Lan 1,4; Liu, Hao-Miao 1,4; Chen, Dong 1,4; Liu, Dan-Dan 2,3; Qin, Hong-Bo1
刊名	ORGANIC LETTERS
	2019-09-06
卷号	21 期号:17 页码:6761-6764
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b02391
通讯作者	Liu, Dan-Dan(liudandan1017@qq.com) ; Qin, Hong-Bo(qinhongbo@mail.kib.ac.cn)
英文摘要	Total synthesis of (+/-)-cochlearol A was accomplished, which features a cis 6/6 B/D ring synthesis. A TMSOTf-promoted lactonization of tert-butoxy ketoester produced the desired lactone with quaternary carbon. The cis configuration of the B/E ring is essential for regioselective B/D ring formation. Finally, simple deprotections and trans- formations gave cochlearol A in 16 steps from known ethyl 4-tert-butoxyacetoacetate.
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000485089300036
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/68713]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Liu, Dan-Dan; Qin, Hong-Bo
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 3.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Da-Wei,Xu, Wen-Dan,Fan, Hui-Lan,et al. Total Synthesis of (+/-)-Cochlearol A[J]. ORGANIC LETTERS,2019,21(17):6761-6764.
APA	Zhang, Da-Wei.,Xu, Wen-Dan.,Fan, Hui-Lan.,Liu, Hao-Miao.,Chen, Dong.,...&Qin, Hong-Bo.(2019).Total Synthesis of (+/-)-Cochlearol A.ORGANIC LETTERS,21(17),6761-6764.
MLA	Zhang, Da-Wei,et al."Total Synthesis of (+/-)-Cochlearol A".ORGANIC LETTERS 21.17(2019):6761-6764.