Three new C23 steroids from the leaves and stems of Nicandra physaloides

doi:10.1016/j.steroids.2019.06.001

	Three new C23 steroids from the leaves and stems of Nicandra physaloides
	Zhang, Ling 1,2; Peng, Xingrong 2; Zhao, Gaoting 2; Xia, Jianjun 1; Lu, Jing 2; Zhou, Lin 2; Wang, Kunmiao 1; Li, Zhihua 1; Qiu, Minghua2
刊名	STEROIDS
	2019-10-01
卷号	150 页码:4
关键词	Nicandra physaloides Solanaceae Withanolide C23 steroids
ISSN号	0039-128X
DOI	10.1016/j.steroids.2019.06.001
通讯作者	Qiu, Minghua(mhchiu@mail.kib.ac.cn)
英文摘要	Nicandra physaloides is a medicinal and edible plant and has been used as traditionally herbal medicine to treat various diseases in folk. Its characteristic withanolides, a kind of ergostane-type steroids, are reported to display plentiful biological activities that many explain the effect of N. physaloides to some extent. Thus, to further find bioactive steroids, the stems and leaves of N. physaloides were investigated and three new C23 steroids, nic-physatones I-J (1-2), and nic-physatone S (3), together with a known C25 steroid, nic 17 (4), were isolated. Their structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, H-1-(1) H COSY, and ROESY), UV and MS analyses. Compounds 1-3 possess a rare C23 steroid skeleton. Among them, compound 3 represented the first example of a C23 steroid featuring a benzene ring (D ring). The isolated compounds showed no cytotoxic activity.
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
WOS记录号	WOS:000486110300002
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/68677]
专题	中国科学院昆明植物研究所
通讯作者	Qiu, Minghua
作者单位	1.China Tobacco Yunnan Ind Co Ltd, R&D Ctr, Yunnan Key Lab Tobacco Chem, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ling,Peng, Xingrong,Zhao, Gaoting,et al. Three new C23 steroids from the leaves and stems of Nicandra physaloides[J]. STEROIDS,2019,150:4.
APA	Zhang, Ling.,Peng, Xingrong.,Zhao, Gaoting.,Xia, Jianjun.,Lu, Jing.,...&Qiu, Minghua.(2019).Three new C23 steroids from the leaves and stems of Nicandra physaloides.STEROIDS,150,4.
MLA	Zhang, Ling,et al."Three new C23 steroids from the leaves and stems of Nicandra physaloides".STEROIDS 150(2019):4.