New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus

doi:10.1016/j.fitote.2019.04.006

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus
	Gu, Chen 1; Yin, Ai-Ping 3; Yuan, Hao-Yang 1; Yang, Kong 1; Luo, Jia 1; Zhan, Ying-Jun 2; Yang, Chong-Ren 2; Zuo, Da-Min 3; Li, Hai-Zhou 1; Xu, Min 1
刊名	FITOTERAPIA
	2019-09-01
卷号	137 页码:7
关键词	Phyllanthus acidus Norbisabolane-type sesquiterpenoid Anti-HBV
ISSN号	0367-326X
DOI	10.1016/j.fitote.2019.04.006
通讯作者	Li, Hai-Zhou(haizhouli@hotmail.com) ; Xu, Min(xumin8121@hotmail.com)
英文摘要	The norbisabolane-type sesquiterpenoids bearing a spiroketal functionality have been found in Phyllanthus spp. and showed anti-HBV activities. As part of an ongoing effort to search for promising anti-HBV sesquiterpenes from Phyllanthus plants, we report four new norbisabolane-type sesquiterpenoids, phyacidusin A (1), phyacidusin B (2), phllanthacidoid A1 (3) and phllanthacidoid N1 (4), from stem of P. acidus collected in Xishuangbanna, Yunnan province, China. The absolute configuration of new compounds was established by coupling constants and ROESY correlations, as well as comparation of NMR data with those of known compounds. The absolute configuration of new compounds 1 and 2 was further confirmed by X-ray diffraction. Compound 2 showed effect to HBsAg with an IC50 value of 11.2 +/- 0.01 mu M, while compound 3 inhibited HBeAg secretion with an IC50 value of 57.1 +/- 0.02 mu M. The results enriched the diversity of anti-HBV norbisabolane sesquiterpenes.
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000484878400060
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/68603]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Li, Hai-Zhou; Xu, Min
作者单位	1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Ctr Pharmaceut Sci, Chenggong Campus, Kunming 650500, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Southern Med Univ, Sch Basic Med Sci, Dept Immunol, Guangzhou 510515, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Gu, Chen,Yin, Ai-Ping,Yuan, Hao-Yang,et al. New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus[J]. FITOTERAPIA,2019,137:7.
APA	Gu, Chen.,Yin, Ai-Ping.,Yuan, Hao-Yang.,Yang, Kong.,Luo, Jia.,...&Xu, Min.(2019).New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus.FITOTERAPIA,137,7.
MLA	Gu, Chen,et al."New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus".FITOTERAPIA 137(2019):7.