Whole-brain mapping of projection from mouse lateral septal nucleus

doi:10.1242/bio.043554

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Whole-brain mapping of projection from mouse lateral septal nucleus
	Deng, Ke 2,3; Yang, Lu 1; Xie, Jing 2,3; Tang, He 3; Wu, Gui-Sheng1 ; Luo, Huai-Rong1,3
刊名	BIOLOGY OPEN
	2019-07-01
卷号	8 期号:7 页码:9
关键词	Lateral septal nucleus H129 PRV Neural circuits Neural projection
ISSN号	2046-6390
DOI	10.1242/bio.043554
通讯作者	Luo, Huai-Rong(luohuairong@mail.kib.ac.cn)
英文摘要	The lateral septal nucleus (LS) plays a critical role in emotionality, social behavior and feeding processes, through neural connections with the hippocampus and hypothalamus. We investigated the neural circuits of LS by using herpes simplex virus 1 strain H129 (H129) and pseudorabies virus stain Bartha (PRV). Virus H129 indicates that LS directly projects to some cerebral nuclei (nucleus accumbens, bed nuclei of the stria terminalis and amygdala), part of the hypothalamus (median preoptic, paraventricular, dorsomedial nucleus and lateral area), thalamus (medial habenula, the paraventricular, parataenial and reuniens nuclei, and the medial line nuclei) and the pontine central gray. Then the LS has secondary projections to the CA3 and CA1 field of the hippocampal formation, lateral and medial preoptic area, and the mammillary body. PRV tracing shows that LS are mainly receiving primary inputs from the amygdala, hippocampus, hypothalamic, thalamus, midbrain and hindbrain, and secondary inputs from dorsal and central linear nucleus raphe, the lateral part of the superior central nucleus raphe, the ventral anterior-lateral complex, the intermediodorsal nucleus, the central medial nucleus, the rhomboid nucleus, and the submedial nucleus of the thalamus. The neural circuit data revealed here could help to understand and further research on the function of LS.
WOS研究方向	Life Sciences & Biomedicine - Other Topics
语种	英语
WOS记录号	WOS:000478023300015
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/68229]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Luo, Huai-Rong
作者单位	1.Southwest Med Univ, Sch Pharm, Dept Pharmacol, Key Lab Aging & Regenerat Med, Luzhou 646000, Sichuan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Deng, Ke,Yang, Lu,Xie, Jing,et al. Whole-brain mapping of projection from mouse lateral septal nucleus[J]. BIOLOGY OPEN,2019,8(7):9.
APA	Deng, Ke,Yang, Lu,Xie, Jing,Tang, He,Wu, Gui-Sheng,&Luo, Huai-Rong.(2019).Whole-brain mapping of projection from mouse lateral septal nucleus.BIOLOGY OPEN,8(7),9.
MLA	Deng, Ke,et al."Whole-brain mapping of projection from mouse lateral septal nucleus".BIOLOGY OPEN 8.7(2019):9.