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	Pulsatile once-a-day-delivery systems for minocycline
	SHETH NITIN VADILAL; VALOROSE JOSEPH JAMES JR.; ELLWAY KEITH ANTHONY; GANESAN MADURAI GURUSAMY; MOONEY KEIRAN GEORGE; JOHNSON JERRY BAIN
	2004-10-05
著作权人	WYETH HOLDINGS CORPORATION
专利号	CA2090561C
国家	加拿大
文献子类	授权发明
其他题名	Pulsatile once-a-day-delivery systems for minocycline
英文摘要	Pharmaceutical delivery systems containing 7-dimethyl 6-deoxy 6-demethyltetracycline or a non-toxic acid addition salt thereof comprising mixtures of a minor proportion of slow-release blended polymer coated spherical granules adapted to release part of the minocycline in a medium having a pH of below 3.9 and the rest in the range of from about 4.0 to about 7.5 and a major proportion of coated or uncoated quick-release granules adapted to release minocycline in a medium having a pH of lass than about 3.9 and oral dosage unit form capsules containing the above are provided. These systems and formulations provide enhanced therapeutic blood levels of minocycline for at least about 24 hours when administered to a subject only once-a-day, regardless of whether the patient is fed or fasted. Methods for the preparation of the systems and formulations are provided as well.
公开日期	1993-09-03
申请日期	1993-02-26
状态	失效
内容类型	专利
源URL	[http://ir.opt.ac.cn/handle/181661/47545]
专题	半导体激光器专利数据库
作者单位	WYETH HOLDINGS CORPORATION
推荐引用方式 GB/T 7714	SHETH NITIN VADILAL,VALOROSE JOSEPH JAMES JR.,ELLWAY KEITH ANTHONY,et al. Pulsatile once-a-day-delivery systems for minocycline. CA2090561C. 2004-10-05.

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