Comparison of Hair Fatty Alcohols by N-Alkylpyridinium Isotope Quaternization and Matrix-assisted Laser Desorption/ionization Mass Spectrometry for Drug Abuse Monitoring

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	Comparison of Hair Fatty Alcohols by N-Alkylpyridinium Isotope Quaternization and Matrix-assisted Laser Desorption/ionization Mass Spectrometry for Drug Abuse Monitoring
	Wang H(汪航) ; Wang HY(王昊阳) ; Zhang L(张立) ; Zhang J(张菁) ; Zhuo XY(卓先义) ; Huang Y(黄懿) ; Guo YL(郭寅龙)
刊名	Chin. J. Chem.
	2012
卷号	30 期号:10 页码:2376-2382
ISSN号	1001-604X
其他题名	氮烷基吡啶同位素季胺化结合基质辅助激光解析离子化质谱比较吸毒者头发脂肪醇含量
通讯作者	郭寅龙
英文摘要	Based on our previous report on N-alkylpyridinium isotope quaternization (NAPIQ) for the analysis of alcoholic and alpha,beta-unsaturated ketone compounds, we have further applied NAPIQ method in the screening of hair lipids in drug abusers. Relative isotopic quantification was used for comparison of fatty alcohols between normal and drug abuse group. The NAPIQ strategy was proven to be a high-throughput method in the metabolic comparison studies of different group samples. The attached N-cationic pyridinium significantly improved the detection sensitivity for these fatty alcohols in matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric (MALDI-FTMS) analysis. The experimental results showed that the levels of fatty alcohols in the hair of heroin abuse group decreased significantly compared with the normal groups, which may be the results of the inducing of peroxidation enzyme. NAPIQ was proven to be an effective and alternative method in the research of fatty alcoholic metabolism for drug abuse monitoring.
学科主题	分析化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/cjoc.201200547
语种	英语
WOS记录号	WOS:000310425500019
公开日期	2013-08-29
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/28655]
专题	上海有机化学研究所_分析化学研究室
推荐引用方式 GB/T 7714	Wang H,Wang HY,Zhang L,et al. Comparison of Hair Fatty Alcohols by N-Alkylpyridinium Isotope Quaternization and Matrix-assisted Laser Desorption/ionization Mass Spectrometry for Drug Abuse Monitoring[J]. Chin. J. Chem.,2012,30(10):2376-2382.
APA	汪航.,王昊阳.,张立.,张菁.,卓先义.,...&郭寅龙.(2012).Comparison of Hair Fatty Alcohols by N-Alkylpyridinium Isotope Quaternization and Matrix-assisted Laser Desorption/ionization Mass Spectrometry for Drug Abuse Monitoring.Chin. J. Chem.,30(10),2376-2382.
MLA	汪航,et al."Comparison of Hair Fatty Alcohols by N-Alkylpyridinium Isotope Quaternization and Matrix-assisted Laser Desorption/ionization Mass Spectrometry for Drug Abuse Monitoring".Chin. J. Chem. 30.10(2012):2376-2382.