The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis

doi:10.1155/2018/3429261

	The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis
	Cheng, Wei 2; Wang, Hongzhi 3; Yuan, Juanjuan 1; Cheng, Ziwei 2; Xing, Dongwei 2; Zhang, Minguang 2
刊名	BIOMED RESEARCH INTERNATIONAL
	2018
页码	10
ISSN号	2314-6133
DOI	10.1155/2018/3429261
通讯作者	Xing, Dongwei(xdw021@163.com) ; Zhang, Minguang(mgzhang09@163.com)
英文摘要	Background. Recent several studies have showed that the nanog overexpression leads to poor prognosis in some kinds of cancer including hepatocellular carcinoma and gastrointestinal luminal cancer. However, the correlations between prognosis and clinic-pathological features and nanog overexpression in lung cancer are still not well-known. Thus, we performed a meta-analysis to evaluate the role of nanog in lung cancer. Methods. An electronic retrieval for related studies was conducted in PubMed, Cochrane Library, Web of Science, EMBASE databases, Chinese CNKI, and the Chinese Wan Fang database up to May 2018. The relationships between nanog overexpression and overall survival (OS) and disease-free survival (DFS) as well as clinic-pathological features in lung cancer were investigated. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by STATA12. Results. 11 studies containing 1422 patients were identified in our meta-analysis. The overexpression of nanog showed decreased OS (HR = 1.83, 95% CI = 1.49-2.25, P 0.001) and DFS (HR = 1.86, 95% CI = 1.2-2.9, P = 0.006). Moreover, overexpression of nanog was significantly related to differentiation (OR = 4.17, 95% CI = 2.17-6.43, P 0.001), lymph node metastasis (OR = 1.76, 95% CI = 1.06-2.91, P = 0.028) and tumor size (OR = 1.93, 95% CI = 1.17-3.20, P = 0.010), and no correlation with T stage, TNM, stage, and gender. Conclusions. Our results suggested that nanog overexpression, a hazard factor of differentiation, lymph node metastasis, and tumor size, may predicate decreased OS and DFS for lung cancer.
资助项目	National Natural Science Foundation of China[81673743]
WOS关键词	STEM-CELLS ; STATISTICS ; EXPRESSION ; MARKER
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000453720300001
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/41140]
专题	中国科学院合肥物质科学研究院
通讯作者	Xing, Dongwei; Zhang, Minguang
作者单位	1.Anhui Med Univ, Peoples Hosp Hefei 2, Hefei Hosp, Hefei 230011, Anhui, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China 3.Chinese Acad Sci, Canc Hosp, Hefei 230011, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Wei,Wang, Hongzhi,Yuan, Juanjuan,et al. The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis[J]. BIOMED RESEARCH INTERNATIONAL,2018:10.
APA	Cheng, Wei,Wang, Hongzhi,Yuan, Juanjuan,Cheng, Ziwei,Xing, Dongwei,&Zhang, Minguang.(2018).The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis.BIOMED RESEARCH INTERNATIONAL,10.
MLA	Cheng, Wei,et al."The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis".BIOMED RESEARCH INTERNATIONAL (2018):10.