Enhancing the sensitivity of ion mobility spectrometry using the ion enrichment effect of non-uniform electrostatic field

doi:10.1016/j.snb.2019.05.088

	Enhancing the sensitivity of ion mobility spectrometry using the ion enrichment effect of non-uniform electrostatic field
	Chen, Chuang 2; Chen, Hong 1,2; Jiang, Dandan 2; Li, Mei 1,2; Huang, Wei 2; Li, Haiyang 2
刊名	SENSORS AND ACTUATORS B-CHEMICAL
	2019-09-15
卷号	295 页码:179-185
关键词	Ion mobility spectrometry Sensitivity Non-uniform electrostatic field Ion enrichment SIMION simulation
ISSN号	0925-4005
DOI	10.1016/j.snb.2019.05.088
通讯作者	Li, Haiyang(hli@dicp.ac.cn)
英文摘要	The diversified applications of ion mobility spectrometry (IMS) frequently pose challenges to the sensitivity of IMS measurements. In this work, the ion density evolution profiles of a continuous flow of ions travelling in nonuniform electrostatic fields were studied. Based on that, an ion enrichment method was proposed for enhancing the sensitivity of IMS. It employed a gradually weakening electrostatic field in the ionization region of IMS and achieved ion density enhancement for the ion flow migrating from the ion source to the ion shutter. Using that method, the ion density of the ion flow produced by the ion source was increased by 180% when approaching the ion shutter. With the increased ion density, the limit of detection (LOD) for DMMP dimer peak was lowered from 425 to 200 pptv. Meanwhile, there was a slight reduction in the resolving power, which was tentatively assigned to the enhanced coulomb repulsion along with the increased ion density. The resolving power of the IMS with a drift length of 60mm was still maintained around 80 at 100 degrees Celsius. The ion enrichment method needs no radial-confining radio frequency voltage. Also, it does not affect the response speed of IMS.
资助项目	National Key R&D Program of China[2016YFC0201200] ; National Key R&D Program of China[2016YFC0800902] ; National Natural Science Foundation of China[21405158] ; Dalian Institute of Chemical Physics[DICP ZZBS201709] ; Dalian Institute of Chemical Physics[DICP ZZBS201801] ; Scientific Study Project of Liaoning Province Educational Commission of China[LQ201715001] ; CAS President's International Fellowship Initiative[2019VEA0033]
WOS关键词	MASS-SPECTROMETRY ; RESOLVING POWER ; GATE
WOS研究方向	Chemistry ; Electrochemistry ; Instruments & Instrumentation
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000469849800022
资助机构	National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China ; CAS President's International Fellowship Initiative ; CAS President's International Fellowship Initiative ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China ; CAS President's International Fellowship Initiative ; CAS President's International Fellowship Initiative ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China ; CAS President's International Fellowship Initiative ; CAS President's International Fellowship Initiative ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China ; CAS President's International Fellowship Initiative ; CAS President's International Fellowship Initiative
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/172123]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Li, Haiyang
作者单位	1.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Chen, Chuang,Chen, Hong,Jiang, Dandan,et al. Enhancing the sensitivity of ion mobility spectrometry using the ion enrichment effect of non-uniform electrostatic field[J]. SENSORS AND ACTUATORS B-CHEMICAL,2019,295:179-185.
APA	Chen, Chuang,Chen, Hong,Jiang, Dandan,Li, Mei,Huang, Wei,&Li, Haiyang.(2019).Enhancing the sensitivity of ion mobility spectrometry using the ion enrichment effect of non-uniform electrostatic field.SENSORS AND ACTUATORS B-CHEMICAL,295,179-185.
MLA	Chen, Chuang,et al."Enhancing the sensitivity of ion mobility spectrometry using the ion enrichment effect of non-uniform electrostatic field".SENSORS AND ACTUATORS B-CHEMICAL 295(2019):179-185.