Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery

doi:10.1007/s00343-019-8127-8

	Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery
	Yu Weiting 1; Zhang Demeng 2,4; Liu Xiudong 3; Wang Yunhong 3; Tong Jun 3; Zhang Mengxue 4; Ma Xiaojun 5
刊名	JOURNAL OF OCEANOLOGY AND LIMNOLOGY
	2019-05-01
卷号	37 期号:3 页码:855-862
关键词	hydrophobic modification sodium alginate-vinyl acetate amphiphilic Alg-g-PVAc/chitosan microcapsules drug delivery
ISSN号	2096-5508
DOI	10.1007/s00343-019-8127-8
通讯作者	Yu Weiting(yuwt@dicp.ac.cn) ; Zhang Demeng(zdm@bmscn.com)
英文摘要	To overcome the fast or burst release of hydrophilic drugs from hydrophilic alginate-based carriers, hydrophobic molecule (vinyl acetate, VAc) was grafted on alginate (Alg), which was further used to prepare drug carriers. Amphiphilic Alg-g-PVAc hydrogel beads were firstly prepared by emulsification/internal gelation technique for the loading of bovine serum albumin (BSA). Then, chitosan was coated on the surface of beads to form novel amphiphilic Alg-g-PVAc/chitosan (Alg-g-PVAc/CS) microcapsules. The BSA-loading amphiphilic Alg-g-PVAc/chitosan (Alg-g-PVAc/CS) microcapsules display similar morphology and size to the hydrophilic alginate/chitosan (AC) microcapsules. However, the drug loading and loading efficiency of BSA in Alg-g-PVAc/CS microcapsules are higher, and the release rate of BSA from Alg-g-PVAc/CS microcapsules is slower. The results demonstrate that the introduction of hydrophobic PVAc on alginate can effectively help retard the release of BSA, and the higher degree of substitution is, the slower the release rate is. In addition, the complex membrane can also be adjusted to delay the release of BSA. As a whole, amphiphilic sodium alginate-vinyl acetate/CS microparticles could be developed for macromolecular drug delivery.
资助项目	National Natural Science Foundation of China[21276033] ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances[SKL-BASS1711] ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances[SKL-BASS1707] ; National Undergraduates Innovation and Entrepreneurship Training Program of China[201711258000001]
WOS关键词	RELEASE
WOS研究方向	Marine & Freshwater Biology ; Oceanography
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000469401600009
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances ; National Undergraduates Innovation and Entrepreneurship Training Program of China ; National Undergraduates Innovation and Entrepreneurship Training Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances ; National Undergraduates Innovation and Entrepreneurship Training Program of China ; National Undergraduates Innovation and Entrepreneurship Training Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances ; National Undergraduates Innovation and Entrepreneurship Training Program of China ; National Undergraduates Innovation and Entrepreneurship Training Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances ; National Undergraduates Innovation and Entrepreneurship Training Program of China ; National Undergraduates Innovation and Entrepreneurship Training Program of China
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171982]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Yu Weiting; Zhang Demeng
作者单位	1.Dalian Univ, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China 3.Dalian Univ, Coll Environm & Chem Engn, Dalian Econ Technol Dev Zone, Dalian 116622, Peoples R China 4.Qingdao Brightmoon Seaweed Grp Co Ltd, State Key Lab Bioact Seaweed Subst, Qingdao 266400, Shandong, Peoples R China 5.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Yu Weiting,Zhang Demeng,Liu Xiudong,et al. Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2019,37(3):855-862.
APA	Yu Weiting.,Zhang Demeng.,Liu Xiudong.,Wang Yunhong.,Tong Jun.,...&Ma Xiaojun.(2019).Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,37(3),855-862.
MLA	Yu Weiting,et al."Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery".JOURNAL OF OCEANOLOGY AND LIMNOLOGY 37.3(2019):855-862.