A Facile One-Pot Process for the Formation of Hindered Tertiary Amines

	A Facile One-Pot Process for the Formation of Hindered Tertiary Amines
	Wang, Zhouyu ; Pei, Dong ; Zhang, Yu ; Wang, Chao ; Sun, Jian
刊名	MOLECULES
	2012
卷号	17 期号:5 页码:5151-5163
关键词	reductive amination tertiary amine Lewis base trichlorosilane ketone
ISSN号	1420-3049
通讯作者	Wang, ZY (reprint author), Xihua Univ, Dept Pharmaceut Engn, Chengdu 610039, Peoples R China ; Sun, Jian
产权排序	2
英文摘要	A simple and convenient method was developed for the preparation of hindered tertiary amines via direct reductive amination of ketones with secondary aryl amines, using trichlorosilane as reducing agent and tetramethylethylenediamine (TMEDA) as organic Lewis base activator. A broad range of ketones were reacted with N-methylaniline to afford the corresponding tertiary amine products in high yield. An open transition model was proposed for the reductive step.
学科主题	Chemistry
收录类别	SCI
资助信息	National Natural Science Foundation of China [21102115, 20972152, 91013006]
语种	英语
WOS记录号	WOS:000304587600031
公开日期	2013-07-03
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/23897]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Wang, Zhouyu,Pei, Dong,Zhang, Yu,et al. A Facile One-Pot Process for the Formation of Hindered Tertiary Amines[J]. MOLECULES,2012,17(5):5151-5163.
APA	Wang, Zhouyu,Pei, Dong,Zhang, Yu,Wang, Chao,&Sun, Jian.(2012).A Facile One-Pot Process for the Formation of Hindered Tertiary Amines.MOLECULES,17(5),5151-5163.
MLA	Wang, Zhouyu,et al."A Facile One-Pot Process for the Formation of Hindered Tertiary Amines".MOLECULES 17.5(2012):5151-5163.