Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH

	Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH
	Zhao L ; Ding JX ; Xiao CS ; He P ; Tang ZH ; Pang X ; Zhuang XL ; Chen XS
刊名	journal of materials chemistry
	2012
卷号	22 期号:24 页码:12319-12328
关键词	RESPONSIVE CONTROLLED-RELEASE DRUG-DELIVERY IN-VIVO POLY(L-GLUTAMIC ACID) SYSTEM COPOLYMERS POLYMERIZATION MICROGELS NANOGELS VITRO
ISSN号	0959-9428
通讯作者	chen xs
中文摘要	three novel phenylboronic acid functionalized block copolymers, monomethoxy poly(ethylene glycol)b-poly(l-glutamic acid-co-n-3-l-glutamylamidophenylboronic acid) (mpeg-b-p(ga-co-gpba)), were synthesized by modifying mpeg-b-pga with 3-aminophenylboronic acid (apba). the resultant diblock copolymers self-assembled into micelles in phosphate buffer at physiological ph (ph 7.4). more interestingly, at ph 7.4, the hydrodynamic radii (r-h) of the micelles increased with an increase in glucose concentration by formation of hydrophilic pba-glucose complex. thus, insulin, a model drug, was loaded into the glucose-sensitive polypeptide micelles. the in vitro release profiles revealed that the release of insulin from the micelles could be triggered by glucose, i.e. less insulin was released under healthy blood glucose level (1 mg ml(-1) glucose), while quick release occurred under diabetic blood glucose level (above 2 mg ml(-1) glucose). furthermore, in vitro methyl thiazolyl tetrazolium (mtt) assays and hemolysis tests suggested that the copolymers had good biocompatibility. therefore, the phenylboronic acid functionalized block copolymers with high glucose-sensitivity and good biocompatibility may have potential as self-regulated insulin release systems.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000304561900063
公开日期	2013-06-30
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48549]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhao L,Ding JX,Xiao CS,et al. Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH[J]. journal of materials chemistry,2012,22(24):12319-12328.
APA	Zhao L.,Ding JX.,Xiao CS.,He P.,Tang ZH.,...&Chen XS.(2012).Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH.journal of materials chemistry,22(24),12319-12328.
MLA	Zhao L,et al."Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH".journal of materials chemistry 22.24(2012):12319-12328.