Hybrid mesoporous gadolinium oxide nanorods: a platform for multimodal imaging and enhanced insoluble anticancer drug delivery with low systemic toxicity

	Hybrid mesoporous gadolinium oxide nanorods: a platform for multimodal imaging and enhanced insoluble anticancer drug delivery with low systemic toxicity
	Liu Z ; Liu X ; Yuan QH ; Dong K ; Jiang LY ; Li ZQ ; Ren JS ; Qu XG
刊名	journal of materials chemistry
	2012
卷号	22 期号:30 页码:14982-14990
关键词	IN-VIVO MAGNETIC-RESONANCE CONTRAST AGENTS SILICA NANOPARTICLES HEMOLYTIC-ACTIVITY QUANTUM DOTS LUMINESCENT THERAPY BIODISTRIBUTION NANOPHOSPHORS
ISSN号	0959-9428
通讯作者	ren js
中文摘要	we present a facile and scalable method to synthesize pegylated eu3+ doped mesoporous gadolinium oxide nanorods for multifunctional biomaterials. by incorporating a facile hydrothermal method, an in situ thermal decomposition process and a surface-modified procedure together, the resultant pegylated gd2o3: eu nanorods reveal rod-like morphology, perfect photoluminescent/magnetic properties, as well as well-defined mesopores. cell-cytotoxicity assays, hemolyticity against human red blood cells and post-injection histology analysis further demonstrate the excellent biocompatibility of the multifunctional nanorods, indicating the feasibility for their use in disease diagnosis and chemotherapy. the capability of nanorods as contrast agents for mr/x-ray/pl imaging is evaluated in detail through preliminary in vivo characterization. moreover, to overcome the limitations of insoluble anticancer drugs in clinical applications, we further develop a simple but efficient method to prepare hydrophobic drug (camptothecin) nanocrystallites in the inner voids of nanorods and testify their enhanced chemotherapy efficiency. our findings indicate the enhanced chemotherapy efficiency of cpt nanocrystallite-loaded nanorods over traditional cpt-loaded nanoparticles. due to these advantages, the well-designed pegylated gd2o3: eu nanorods are promising for a simultaneous bioimaging and drug delivery system, which show further potential for clinical applications.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000306215900026
公开日期	2013-06-30
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48510]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu Z,Liu X,Yuan QH,et al. Hybrid mesoporous gadolinium oxide nanorods: a platform for multimodal imaging and enhanced insoluble anticancer drug delivery with low systemic toxicity[J]. journal of materials chemistry,2012,22(30):14982-14990.
APA	Liu Z.,Liu X.,Yuan QH.,Dong K.,Jiang LY.,...&Qu XG.(2012).Hybrid mesoporous gadolinium oxide nanorods: a platform for multimodal imaging and enhanced insoluble anticancer drug delivery with low systemic toxicity.journal of materials chemistry,22(30),14982-14990.
MLA	Liu Z,et al."Hybrid mesoporous gadolinium oxide nanorods: a platform for multimodal imaging and enhanced insoluble anticancer drug delivery with low systemic toxicity".journal of materials chemistry 22.30(2012):14982-14990.