| Bioactive Lignans from the Leaves and Stems of Schisandra wilsoniana | |
Yang, Guang-Yu1,4; Wang, Rui-Rui2,3; Gao, Zhong-Hua1; Li, Yin-Ke1,5; Yang, Liu-Meng2,3; Li, Xiao-Nian1; Shang, Shan-Zhai1; Zheng, Yong-Tang2,3; Xiao, Wei-Lie1; Sun, Han-Dong1
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| 刊名 | NATURAL PRODUCT COMMUNICATIONS
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| 2013-04-01 | |
| 卷号 | 8期号:4页码:467-470 |
| 关键词 | Schisandra wilsoniana Lignans Anti-HIV-1 activities Antitumor activities |
| ISSN号 | 1934-578X |
| 通讯作者 | Xiao, WL (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China. ; xwl@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
| 英文摘要 | Three new dibenzocyclooctadiene lignans, marlignans M-O (1-3), together two known ones, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1-3 were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 2 showed anti-HIV-1 activity with an EC50 value of 5.82 mu g/mL and a therapeutic index (TI) of more than 12.8. Compound 3 showed obvious bioactivity in inhibiting Epstein-Barr virus early antigen (EBV-EA) activation. |
| 学科主题 | Pharmacology & Pharmacy; Food Science & Technology |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Chemistry, Medicinal ; Food Science & Technology |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Food Science & Technology |
| 关键词[WOS] | SCHIZANDRA-CHINENSIS BAILL ; DIBENZOCYCLOOCTADIENE LIGNANS ; KADSURA-PHILIPPINENSIS ; CONSTITUENTS ; FRUITS ; NORTRITERPENOIDS ; INHIBITORS ; VIRUS ; CELLS |
| 收录类别 | SCI |
| 资助信息 | CAS [KSCX2-EW-Q-10, KSCX1-YW-R-24]; Natural Science Foundation of Yunnan Province [2012FB178]; NSFC [20802082, 30830115]; 973 programs [2009CB522300, 2009CB940900]; Young Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]; Key Scientific and Technological Projects of China [2009ZX09501-029] |
| 语种 | 英语 |
| WOS记录号 | WOS:000317810000014 |
| 公开日期 | 2013-06-08 |
| 内容类型 | 期刊论文 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/16471]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan Province, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Yunnan Province, Peoples R China 4.Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Yunnan, Peoples R China 5.Yunnan Nationalities Univ, Sch Chem & Biotechnol, Kunming 650031, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Guang-Yu,Wang, Rui-Rui,Gao, Zhong-Hua,et al. Bioactive Lignans from the Leaves and Stems of Schisandra wilsoniana[J]. NATURAL PRODUCT COMMUNICATIONS,2013,8(4):467-470. |
| APA | Yang, Guang-Yu.,Wang, Rui-Rui.,Gao, Zhong-Hua.,Li, Yin-Ke.,Yang, Liu-Meng.,...&Sun, Han-Dong.(2013).Bioactive Lignans from the Leaves and Stems of Schisandra wilsoniana.NATURAL PRODUCT COMMUNICATIONS,8(4),467-470. |
| MLA | Yang, Guang-Yu,et al."Bioactive Lignans from the Leaves and Stems of Schisandra wilsoniana".NATURAL PRODUCT COMMUNICATIONS 8.4(2013):467-470. |
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