Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia
	Wang, Xiao-Ying 1,2; Tang, Gui-Hua2 ; Yuan, Chun-Mao 2; Zhang, Yu2 ; Zou, Tao 1; Yu, Chun 1; Zhao, Qing 1; Hao, Xiao-Jiang; He, Hong-Ping 1,2
刊名	FITOTERAPIA
	2013-03-01
卷号	85 页码:64-68
关键词	Aphanamixis grandifolia Meliaceae Cycloartane triterpenoids Antibacterial activities
ISSN号	0367-326X
通讯作者	Zhao, Q (reprint author), Yunnan Univ TCM, Fac Pharm, Kunming 650500, Yunnan, Peoples R China. ; tempzhao@126.com ; haoxj@mail.kib.ac.cn ; hehongping@mail.kib.ac.cn
英文摘要	Three new cycloartane triterpenoids, aphagrandinoids A-C (1-3), and a new natural product, aphagrandinoid D (4), together with a known compound, were isolated from the leaves and twigs of Aphanamixis grandifolia. Their structures were elucidated by extensive NMR and MS techniques. Aphagrandinoid A (1), a 29-nor-cycloart triterpenoid, features with a sprio ring system at the side chain, while aphagrandinoid C (3) is a pentnortriterpenoid. Antibacterial activities of these five compounds were also evaluated. Compounds 1 and 5 showed weak antibacterial activities (MIC values: 1.57-3.13 mu g/mL) against Staphylococcus aureus, MRSA 92(#), and MRSA 98(#). (C) 2013 Elsevier B.V. All rights reserved.
学科主题	Pharmacology & Pharmacy
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	KHAYA-SENEGALENSIS ; RING-SYSTEM ; POLYSTACHYA ; LIMONOIDS ; MELIACEAE ; CONSTITUENTS ; SKELETON
收录类别	SCI
资助信息	National Basic Research Program of China (973 Program) [2009CB522300, 2009CB940900]; National Natural Science Funding of China [31170332]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI047]
语种	英语
WOS记录号	WOS:000317172000010
公开日期	2013-06-08
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/16453]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ TCM, Fac Pharm, Kunming 650500, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiao-Ying,Tang, Gui-Hua,Yuan, Chun-Mao,et al. Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia[J]. FITOTERAPIA,2013,85:64-68.
APA	Wang, Xiao-Ying.,Tang, Gui-Hua.,Yuan, Chun-Mao.,Zhang, Yu.,Zou, Tao.,...&He, Hong-Ping.(2013).Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia.FITOTERAPIA,85,64-68.
MLA	Wang, Xiao-Ying,et al."Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia".FITOTERAPIA 85(2013):64-68.