Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma

	Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma
	Lu TC ; Jing XB ; Song XF ; Wang XR
刊名	journal of applied polymer science
	2012
卷号	123 期号:1 页码:209-217
关键词	MULTIFUNCTIONAL MICELLES ANTICANCER DRUG TUMOR-CELLS ADRIAMYCIN INHIBITION FAS/APO-1
ISSN号	0021-8995
通讯作者	lu tc
中文摘要	the purpose of this study was to evaluate both cytotoxicity in vitro and in vivo anticancer activities of implantable doxorubicin hydrocloride (dox)-loaded diblock copolymer poly(ethylene glycol)-b-poly(l-lactic acid) (peg-pla) fiber mats (hereafter medicated mats). for in vitro evaluation, smmc7721 cells were directly exposed to the medicated fiber mats, followed with mtt assay. for in vivo evaluation, the medicated mats were locally implanted into h22 tumor-bearing mice, followed with detection of fas protein and flow cytometry analysis. the results showed that in vitro cytotoxicity of medicated fibers were sustained throughout the whole experiment process with the degradation of fiber matrix, while that of pure dox was reduced in six days; medicated fibers had superior in vivo anticancer activities to pure dox (p < 0.01). in conclusion, doxorubicin-loaded peg-pla electrospun fiber mats had the properties of loading doxorubicin hydrochloride (dox) and sustained release of dox from medicated fiber matrix and apparently retained both in vitro cytotoxicity and in vivo anticancer activities in a long term. medicated fiber mats are therefore suitable for a local therapy device. (c) 2011 wiley periodicals, inc. j appl polym sci 123: 209-217, 2012
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000296437600023
公开日期	2013-06-09
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48407]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Lu TC,Jing XB,Song XF,et al. Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma[J]. journal of applied polymer science,2012,123(1):209-217.
APA	Lu TC,Jing XB,Song XF,&Wang XR.(2012).Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma.journal of applied polymer science,123(1),209-217.
MLA	Lu TC,et al."Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma".journal of applied polymer science 123.1(2012):209-217.