Selective discrimination of small hydrophobic biomolecules based on ion-current rectification in conically shaped nanochannel

	Selective discrimination of small hydrophobic biomolecules based on ion-current rectification in conically shaped nanochannel
	Guo ZJ ; Wang JH ; Wang EK
刊名	talanta
	2012
卷号	89 页码:253-257
关键词	SOLID-STATE NANOPORES RESISTIVE-PULSE SYNTHETIC NANOPORES PROTEIN NANOPORES DNA DETECTION SINGLE TRANSPORT ELECTRODES BIOSENSORS NANOTUBES
ISSN号	0039-9140
通讯作者	wang jh
中文摘要	in this study, based on ion-current rectification in the conically shaped nanochannel embedded in polyethylene terephthalate (pet) membrane, we have selectively discriminated three small biomolecules. because three positive biomolecules (hoechst 33342, propidium and bupivacaine) have different hydrophobicities, their interactions with inside wall of the conical nanochannel are different and their binding affinities can be derived from langmuir absorption model. therefore, we can successfully discriminate these small biomolecules. the highest binding constant was obtained for the small molecule with highest hydrophobicity. another interesting result is that the detection limit for the small molecule with the highest binding constant shifts to submicromole. (c) 2011 elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000301278000037
公开日期	2013-06-08
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48368]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Guo ZJ,Wang JH,Wang EK. Selective discrimination of small hydrophobic biomolecules based on ion-current rectification in conically shaped nanochannel[J]. talanta,2012,89:253-257.
APA	Guo ZJ,Wang JH,&Wang EK.(2012).Selective discrimination of small hydrophobic biomolecules based on ion-current rectification in conically shaped nanochannel.talanta,89,253-257.
MLA	Guo ZJ,et al."Selective discrimination of small hydrophobic biomolecules based on ion-current rectification in conically shaped nanochannel".talanta 89(2012):253-257.