Lmx1b controls peptide phenotypes in serotonergic and dopaminergic neurons

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	Lmx1b controls peptide phenotypes in serotonergic and dopaminergic neurons
	Yan, R ; Huang, TW ; Xie, ZQ ; Xia, GN ; Qian, H ; Zhao, XL ; Cheng, LP
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2013
卷号	45 期号:5 页码:345-352
关键词	CENTRAL-NERVOUS-SYSTEM SUBSTANCE P-LIKE SPINAL-CORD NEURAL CREST RAT COEXISTENCE BRAIN IMMUNOREACTIVITY SPECIFICATION MIDBRAIN
ISSN号	1672-9145
通讯作者	Cheng, LP (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,lpcheng@ion.ac.cn
英文摘要	Serotonin (5-HT) neurons synthesize a variety of peptides. How these peptides are controlled during development remains unclear. It has been reported that the co-localization of peptides and 5-HT varies by species. In contrast to the situations in the rostral 5-HT neurons of human and rat brains, several peptides do not coexist with 5-HT in the rostral 5-HT neurons of mouse brain. In this study, we found that the peptide substance P and peptide genes, including those encoding peptides thyrotropin-releasing hormone, enkephalin, and calcitonin gene-related peptide, were expressed in the caudal 5-HT neurons of mouse brain; these findings are in line with observations in rat and monkey 5-HT neurons. We also revealed that these peptides/peptide genes partially overlapped with the transcription factor Lmx1b that specifies the 5-HT cell fate. Furthermore, we found that the peptide cholecystokinin was expressed in developing dopaminergic neurons and greatly overlapped with Lmx1b that specifies the dopaminergic cell fate. By examining the phenotype of Lmx1b deletion mice, we found that Lmx1b was required for the expression of above peptides expressed in 5-HT or dopaminergic neurons. Together, our results indicate that Lmx1b, a key transcription factor for the specification of 5-HT and dopaminergic transmitter phenotypes during embryogenesis, determines some peptide phenotypes in these neurons as well.
学科主题	Biochemistry & Molecular Biology ; Biophysics
收录类别	SCI
资助信息	Chinese Academy of Sciences [XDA01020306]
语种	英语
WOS记录号	WOS:000318084700001
公开日期	2013-06-04
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2519]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Yan, R,Huang, TW,Xie, ZQ,et al. Lmx1b controls peptide phenotypes in serotonergic and dopaminergic neurons[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2013,45(5):345-352.
APA	Yan, R.,Huang, TW.,Xie, ZQ.,Xia, GN.,Qian, H.,...&Cheng, LP.(2013).Lmx1b controls peptide phenotypes in serotonergic and dopaminergic neurons.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,45(5),345-352.
MLA	Yan, R,et al."Lmx1b controls peptide phenotypes in serotonergic and dopaminergic neurons".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 45.5(2013):345-352.