Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism

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	Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism
	Du, JL
刊名	NEURON
	2012
卷号	75 期号:4 页码:688-699
关键词	TO-NOISE RATIO MULTISENSORY INTEGRATION LARVAL ZEBRAFISH AUDITORY-CORTEX MAUTHNER CELL TYROSINE-HYDROXYLASE SUPERIOR COLLICULUS SENSORY RESPONSES CEREBRAL-CORTEX MIXED SYNAPSES
ISSN号	0896-6273
通讯作者	Du, JL (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,forestdu@ion.ac.cn
英文摘要	Visual cues often modulate auditory signal processing, leading to improved sound detection. However, the synaptic and circuit mechanism underlying this cross-modal modulation remains poorly understood. Using larval zebrafish, we first established a cross-modal behavioral paradigm in which a preceding flash enhances sound-evoked escape behavior, which is known to be executed through auditory afferents (VIIIth nerves) and command-like neurons (Mauthner cells). In vivo recording revealed that the visual enhancement of auditory escape is achieved by increasing sound-evoked Mauthner cell responses. This increase in Mauthner cell responses is accounted for by the increase in the signal-to-noise ratio of sound-evoked VIIIth nerve spiking and efficacy of VIIIth nerve-Mauthner cell synapses. Furthermore, the visual enhancement of Mauthner cell response and escape behavior requires light-responsive dopaminergic neurons in the caudal hypothalamus and D1 dopamine receptor activation. Our findings illustrate a cooperative neural mechanism for visual modulation of audiomotor processing that involves dopaminergic neuromodulation.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Basic Research Program of China [2011CBA00400, 2012CB945101]; Shanghai government [06dj14010, 07pj14107]; Chinese Academy of Sciences
语种	英语
公开日期	2013-06-04
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2510]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Du, JL. Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism[J]. NEURON,2012,75(4):688-699.
APA	Du, JL.(2012).Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism.NEURON,75(4),688-699.
MLA	Du, JL."Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism".NEURON 75.4(2012):688-699.