A GABAergic Inhibitory Neural Circuit Regulates Visual Reversal Learning in Drosophila

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	A GABAergic Inhibitory Neural Circuit Regulates Visual Reversal Learning in Drosophila
	Guo, AK
刊名	JOURNAL OF NEUROSCIENCE
	2012
卷号	32 期号:34 页码:11524-11538
关键词	MUSHROOM BODIES FLIGHT ORIENTATION OLFACTORY MEMORY ORBITOFRONTAL CORTEX TARGETED EXPRESSION FRUIT-FLY BEHAVIOR BODY BRAIN MELANOGASTER
ISSN号	0270-6474
通讯作者	Guo, AK (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,akguo@ion.ac.cn
英文摘要	Inflexible cognition and behavior are prominent features of prefrontal cortex damage and several neuropsychiatric disorders. The ability to flexibly adapt cognitive processing and behavior to dynamically changing environmental contingencies has been studied using the reversal learning paradigm in mammals, but the complexity of the brain circuits precludes a detailed analysis of the underlying neural mechanism. Here we study the neural circuitry mechanism supporting flexible behavior in a genetically tractable model organism, Drosophila melanogaster. Combining quantitative behavior analysis and genetic manipulation, we found that inhibition from a single pair of giant GABAergic neurons, the anterior paired lateral (APL) neurons, onto the mushroom bodies (MBs) selectively facilitates behavioral flexibility during visual reversal learning. This effect was mediated by ionotropic GABA(A) receptors in the MB. Moreover, flies with perturbed MB output recapitulated the poor reversal performance of flies with dysfunctional APL neurons. Importantly, we observed that flies with dysfunctional APL-MB circuit performed normally in simple forms of visual learning, including initial learning, extinction, and differential conditioning. Finally, we showed that acute disruption of the APL-MB circuit is sufficient to impair visual reversal learning. Together, these data suggest that the APL-MB circuit plays an essential role in the resolution of conflicting reinforcement contingencies and reveals an inhibitory neural mechanism underlying flexible behavior in Drosophila.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	973 Program [2011CBA00400]; Natural Science Foundation of China [30921064, 90820008, 31130027]
语种	英语
公开日期	2013-06-04
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2473]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Guo, AK. A GABAergic Inhibitory Neural Circuit Regulates Visual Reversal Learning in Drosophila[J]. JOURNAL OF NEUROSCIENCE,2012,32(34):11524-11538.
APA	Guo, AK.(2012).A GABAergic Inhibitory Neural Circuit Regulates Visual Reversal Learning in Drosophila.JOURNAL OF NEUROSCIENCE,32(34),11524-11538.
MLA	Guo, AK."A GABAergic Inhibitory Neural Circuit Regulates Visual Reversal Learning in Drosophila".JOURNAL OF NEUROSCIENCE 32.34(2012):11524-11538.