Nanoporous multilayer poly(L-glutamic acid)/chitosan microcapsules for drug delivery

	Nanoporous multilayer poly(L-glutamic acid)/chitosan microcapsules for drug delivery
	Yan SF ; Rao SQ ; Zhu J ; Wang ZC ; Zhang Y ; Duan YR ; Chen XS ; Yin JB
刊名	international journal of pharmaceutics
	2012
卷号	427 期号:2 页码:443-451
关键词	SOLID-STATE NMR HYALURONIC-ACID POLYELECTROLYTE MULTILAYERS MESOPOROUS SILICA RELEASE PARTICLES CAPSULES CHITOSAN MATRICES MACROMOLECULES
ISSN号	0378-5173
通讯作者	yin jb
中文摘要	nanoporous poly(l-glutamic acid)/chitosan (plga/cs) multilayer microcapsules were fabricated by layer-by-layer (lbl) assembly using the porous silica particles as sacrificial templates. the lbl assembled nanoporous plga/cs microcapsules were characterized by zeta-potential analyzer, ftir, tga, sem, tem and clsm. 5-fluorouracil (5-fu) was chosen as model drug. the drug loading content of plga/cs microcapsules depends on loading time, loading temperature, ph value and nacl concentration. high loading capacity of microcapsules can be achieved by simply adjusting ph value and salt concentration. moreover, 5-fu loaded microcapsules take on a sustained release behavior, especially in an acid solution, in contrast to burst release of bare 5-fu. the kinetics of 5-fu release from plga/cs microcapsules conforms to korsmeyer-peppas and baker-lonsdale models, the mechanism of which can be ascribed to priority of drug diffusion and subordination of polymer degradation. the mtt cytotoxicity assay in vitro reveals the satisfactory anticancer activity of the drug-loaded plga/cs microcapsules. therefore, the novel nanoporous plga/cs microcapsules is expected to find application in drug delivery systems. (c) 2012 elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000302364500039
公开日期	2013-05-20
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48173]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Yan SF,Rao SQ,Zhu J,et al. Nanoporous multilayer poly(L-glutamic acid)/chitosan microcapsules for drug delivery[J]. international journal of pharmaceutics,2012,427(2):443-451.
APA	Yan SF.,Rao SQ.,Zhu J.,Wang ZC.,Zhang Y.,...&Yin JB.(2012).Nanoporous multilayer poly(L-glutamic acid)/chitosan microcapsules for drug delivery.international journal of pharmaceutics,427(2),443-451.
MLA	Yan SF,et al."Nanoporous multilayer poly(L-glutamic acid)/chitosan microcapsules for drug delivery".international journal of pharmaceutics 427.2(2012):443-451.