Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency

	Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency
	Jin J ; Jiang W ; Shi Q ; Zhao J ; Yin JH ; Stagnaro P
刊名	applied surface science
	2012
卷号	258 期号:15 页码:5841-5849
关键词	POLY(ETHYLENE GLYCOL) DERIVATIVES BLOOD COMPATIBILITY POLYETHYLENE OXIDE SURFACE INTERACTIONS IMMOBILIZED HEPARIN PLATELET-ADHESION ADSORBED PROTEINS IN-VITRO PLASMA ALBUMIN
ISSN号	0169-4332
通讯作者	jiang w
中文摘要	we described a two-step process to fabricate the heparinized polypropylene (pp) film using cyanuric chloride (cc) as a trifunctional reagent and poly (ethylene glycol) methacrylate (pegma) as a spacer. the modified pp films were characterized by attenuated total reflectance ft-ir and x-ray photoelectron spectroscopy; the content of pegma and heparin were determined by gravimetric method and a toluidine blue assay, respectively. for the pp-g-pegma films, it was found that small size protein bsa tended to adsorb on the surface of low molecular weight monomer grafted pp, whereas big spindle-shaped fibrinogen tended to adsorb on the surface of high molecular weight monomer grafted pp. we gave a definition of anti-protein adsorptive factor r with two model proteins, albumin and fibrinogen. the results by platelet adhesion and plasma recalcification time (prt) experiments indicated that the factor r could be used to quantitatively evaluate the anticoagulant tendency of pp-g-pegma modified films. for the pp-g-pegma-g-heparin modified films, the surface was proved to have a high bioactivity by the adsorption of at iii assay and very low platelet adhesion. it indicated that immobilization of heparin on the pp film with pegma as a spacer was an effective way to improve the hemocompatibility of pp. crown copyright (c) 2012 published by elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000302135700052
公开日期	2013-05-20
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48169]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Jin J,Jiang W,Shi Q,et al. Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency[J]. applied surface science,2012,258(15):5841-5849.
APA	Jin J,Jiang W,Shi Q,Zhao J,Yin JH,&Stagnaro P.(2012).Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency.applied surface science,258(15),5841-5849.
MLA	Jin J,et al."Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency".applied surface science 258.15(2012):5841-5849.