Graphene-Based Aptamer Logic Gates and Their Application to Multiplex Detection

	Graphene-Based Aptamer Logic Gates and Their Application to Multiplex Detection
	Wang L ; Zhu JB ; Han L ; Jin LH ; Zhu CZ ; Wang EK ; Dong SJ
刊名	acs nano
	2012
卷号	6 期号:8 页码:6659-6666
关键词	LABEL-FREE GOLD NANOPARTICLES THROMBIN DETECTION MAGNETIC BEADS DNA APTAMER SELECTION OXIDE ENRICHMENT MOLECULES ADENOSINE
ISSN号	1936-0851
通讯作者	wang ek
中文摘要	in this work, a go/aptamer system was constructed to create multiplex logic operations and enable sensing of multiplex targets. 6-carboxy-fluorescein (fam)-labeled adenosine triphosphate binding aptamer (aba) and fam-labeled thrombin binding aptamer (tba) were first adsorbed onto graphene oxide (go) to form a go/aptamer complex, leading to the quenching of the fluorescence of fam. we demonstrated that the unique go/aptamer interaction and the specific aptamer target recognition in the target/go/aptamer system were programmable and could be utilized to regulate the fluorescence of fam via or and inhibit logic gates. the fluorescence changed according to different input combinations, and the integration of or and inhibit logic gates provided an interesting approach for logic sensing applications where multiple target molecules were present. high-throughput fluorescence imagings that enabled the simultaneous processing of many samples by using the combinatorial logic gates were realized. the developed logic gates may find applications in further development of dna circuits and advanced sensors for the identification of multiple targets in complex chemical environments.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000307988900017
公开日期	2013-04-23
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48016]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang L,Zhu JB,Han L,et al. Graphene-Based Aptamer Logic Gates and Their Application to Multiplex Detection[J]. acs nano,2012,6(8):6659-6666.
APA	Wang L.,Zhu JB.,Han L.,Jin LH.,Zhu CZ.,...&Dong SJ.(2012).Graphene-Based Aptamer Logic Gates and Their Application to Multiplex Detection.acs nano,6(8),6659-6666.
MLA	Wang L,et al."Graphene-Based Aptamer Logic Gates and Their Application to Multiplex Detection".acs nano 6.8(2012):6659-6666.