Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates

	Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates
	Mo GJ ; Hu XL ; Liu S ; Yue J ; Wang R ; Huang YB ; Jing XB
刊名	european journal of pharmaceutical sciences
	2012
卷号	46 期号:5 页码:329-335
关键词	HPMA COPOLYMERS BLOCK-COPOLYMER 500-1000 TIMES DRUG CARRIERS DOXORUBICIN DELIVERY MICELLES 2-PYRROLINODOXORUBICIN POTENT ACID)
ISSN号	0928-0987
通讯作者	jing xb
中文摘要	pirarubicin (thp) was conjugated onto the pendant carboxyl groups of poly(ethylene glycol)-block-poly(1-lactide-co-2-methyl-2-carboxyl-propylene carbonate) [peg-b-p( la-co-mcc)] through hydrazone, ester, and amide bonds, respectively, and the conjugates were assembled into micelles with diameters between 30 and 60 nm. the in vitro thp release of the three conjugate micelles was conducted in ph 7.4 and 5.0 buffer solutions, and conjugate micelles with hydrazone linkage had the fastest thp release rate. their in vitro cytotoxicity was tested using mouse mammary adenocarcinoma emt6 cells and in vivo anti-tumor activity in balb/c mice models bearing emt6 tumors were compared with free thp and with each other. the results showed that the polymer-thp conjugates displayed higher cell-uptakes and better antitumor activities than free thp at 4 h, and among the three micelles, those with hydrazone linkage had the highest anti-tumor activity in vivo, while those with amide linkage were the lowest. (c) 2012 elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000305370500005
公开日期	2013-04-23
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48001]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Mo GJ,Hu XL,Liu S,et al. Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates[J]. european journal of pharmaceutical sciences,2012,46(5):329-335.
APA	Mo GJ.,Hu XL.,Liu S.,Yue J.,Wang R.,...&Jing XB.(2012).Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates.european journal of pharmaceutical sciences,46(5),329-335.
MLA	Mo GJ,et al."Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates".european journal of pharmaceutical sciences 46.5(2012):329-335.