Antibacterial activity of ciprofloxacin-loaded zein microsphere films

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	Antibacterial activity of ciprofloxacin-loaded zein microsphere films
	FU JIANXI ; Wang HJ(王华杰) ; ZHOU YANQING ; Wang JY(王瑾晔)
刊名	Mater. Sci. Eng. C-Biomimetic Supramol. Syst.
	2009
卷号	29 期号:4 页码:1161-1166
ISSN号	0928-4931
其他题名	Antibacterial activity of ciprofloxacin-loaded zein microsphere films
通讯作者	王瑾晔
英文摘要	Our aim was to produce an antibiotic-emitting coating composed of zein microspheres for the prevention of bacterial infection oil implanted devices. Ciprofloxacin-loaded zein microspheres were prepared using a phase separation procedure, with particle sizes between 0.5 and 2 mu m. Drug encapsulation and drug loading varied with the amount of both zein and ciprofloxacin. and the highest encapsulation efficiency was 8.27% (2 mg/ml ciprofloxacin and 20 mg/ml zein: n = 3). A ciprofloxacin-loaded zein microsphere film (CF-MS film) was generated via solvent evaporation. Continuous drug release from a trypsin-degraded microsphere film was observed for Up to 28 days. The liberation of ciprofloxacin from the trypsin-degraded film and the biodegradation of the microsphere film were highly correlated. Proliferation assay of the growth of human umbilical vein endothelial cells (HUVECs) by the MTT method showed that the microsphere film had no toxicity when compared with cells grown oil Corning Culture plates alone and plates with a zein film alone. Quantification of bacteria adhesion showed that adhesion on the microsphere film is significantly Suppressed. in addition, according to the results of bacterial growth tests, ciprofloxacin-loaded microsphere films maintained antibacterial activity for more than 6 days, In contrast, a control medium containing a zein film allowed constant bacterial growth. These results indicate that CF-MS films might be useful as,antibacterial films oil implanted devices. (C) 2008 Elsevier B.V. All rights reserved.
学科主题	高分子化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.msec.2008.09.031
语种	英语
WOS记录号	WOS:000269139900017
公开日期	2013-04-11
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/25485]
专题	上海有机化学研究所_上海有机化学研究所
推荐引用方式 GB/T 7714	FU JIANXI,Wang HJ,ZHOU YANQING,et al. Antibacterial activity of ciprofloxacin-loaded zein microsphere films[J]. Mater. Sci. Eng. C-Biomimetic Supramol. Syst.,2009,29(4):1161-1166.
APA	FU JIANXI,王华杰,ZHOU YANQING,&王瑾晔.(2009).Antibacterial activity of ciprofloxacin-loaded zein microsphere films.Mater. Sci. Eng. C-Biomimetic Supramol. Syst.,29(4),1161-1166.
MLA	FU JIANXI,et al."Antibacterial activity of ciprofloxacin-loaded zein microsphere films".Mater. Sci. Eng. C-Biomimetic Supramol. Syst. 29.4(2009):1161-1166.