Desymmetrization of cyclohexadienones via cinchonine derived thiourea-catalyzed enantioselective aza-Michael reaction and total synthesis of (-)-Mesembrine

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	Desymmetrization of cyclohexadienones via cinchonine derived thiourea-catalyzed enantioselective aza-Michael reaction and total synthesis of (-)-Mesembrine
	Gu Q(顾庆) ; You SL(游书力)
刊名	Chem. Sci.
	2011
卷号	2 期号:8 页码:1519-1522
ISSN号	2041-6520
其他题名	通过辛可宁衍生的硫脲催化的不对称氮杂Michael反应实现的环己二烯酮的去对称化以及(-)-Mesembrine的全合成
通讯作者	游书力
英文摘要	Desymmetrization of cyclohexadienones via aza-Michael reaction catalyzed by cinchonine derived thiourea has been realized to afford a series of highly enantioenriched pyrrolidine and morpholine derivatives in excellent yields and ees. With this newly established methodology, asymmetric total synthesis of (-)-Mesembrine in high enantiomeric excess (98% ee) was accomplished.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1039/c1sc00083g
语种	英语
WOS记录号	WOS:000292964700015
公开日期	2013-03-04
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/22544]
专题	上海有机化学研究所_金属有机化学国家重点实验室
推荐引用方式 GB/T 7714	Gu Q,You SL. Desymmetrization of cyclohexadienones via cinchonine derived thiourea-catalyzed enantioselective aza-Michael reaction and total synthesis of (-)-Mesembrine[J]. Chem. Sci.,2011,2(8):1519-1522.
APA	顾庆,&游书力.(2011).Desymmetrization of cyclohexadienones via cinchonine derived thiourea-catalyzed enantioselective aza-Michael reaction and total synthesis of (-)-Mesembrine.Chem. Sci.,2(8),1519-1522.
MLA	顾庆,et al."Desymmetrization of cyclohexadienones via cinchonine derived thiourea-catalyzed enantioselective aza-Michael reaction and total synthesis of (-)-Mesembrine".Chem. Sci. 2.8(2011):1519-1522.