Presence of estrogenic activity from emission of fossil fuel combustion as detected by a recombinant yeast bioassay

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	Presence of estrogenic activity from emission of fossil fuel combustion as detected by a recombinant yeast bioassay
	Wang, JX ; Wu, WZ ; Henkelmann, B ; You, L ; Kettrup, A ; Schramm, KW
刊名	ATMOSPHERIC ENVIRONMENT
	2003-07-01
卷号	37 期号:23 页码:3225-3235
关键词	fossil fuel emission estrogenic activity yeast bioassay
ISSN号	1352-2310
通讯作者	Schramm, KW, GSF, Natl Res Ctr Environm & Hlth, Inst Ecol Chem, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany
中文摘要	Estrogenic activities of emission samples generated by fossil fuel combustion were investigated with human estrogen receptor (ER) recombinant yeast bioassay. The results showed that there were weak but clear estrogenic activities in combustion emissions of fossil fuels including coal, petroleum, and diesel. The estrogenic relative potency (RP) of fossil fuel combustion was the highest in petroleum-fired car, followed by coal-fired stove, diesel-fired agrimotor, coal-fired electric power station. On the other hand, the estrogenic relative inductive efficiency (RIE) was the highest in coal-fired stove and coal-fired electric power station, followed by petroleum-fired car and diesel-fired agrimotor. The estrogenic activities in the sub-fractions from chromatographic separation of emitted materials were also determined. The results indicated that different chemical fractions in these complex systems have different estrogenic potencies. The GC/MS analysis of the emission showed that there were many aromatic carbonyls, big molecular alcohol, PAHs and derivatives, and substituted phenolic compounds and derivatives which have been reported as environmental estrogens. The existence of estrogenic substances in fossil fuel combustion demands further investigation of their potential adverse effects on human and on the ecosystem. The magnitude of pollution due to global usage of fossil fuels makes it imperative to understand the issue of fossil fuel-derived endocrine activities and the associated health risks, particularly the aggregated risks stemmed from exposure to toxicants of multiple sources. (C) 2003 Elsevier Science Ltd. All rights reserved.
英文摘要	Estrogenic activities of emission samples generated by fossil fuel combustion were investigated with human estrogen receptor (ER) recombinant yeast bioassay. The results showed that there were weak but clear estrogenic activities in combustion emissions of fossil fuels including coal, petroleum, and diesel. The estrogenic relative potency (RP) of fossil fuel combustion was the highest in petroleum-fired car, followed by coal-fired stove, diesel-fired agrimotor, coal-fired electric power station. On the other hand, the estrogenic relative inductive efficiency (RIE) was the highest in coal-fired stove and coal-fired electric power station, followed by petroleum-fired car and diesel-fired agrimotor. The estrogenic activities in the sub-fractions from chromatographic separation of emitted materials were also determined. The results indicated that different chemical fractions in these complex systems have different estrogenic potencies. The GC/MS analysis of the emission showed that there were many aromatic carbonyls, big molecular alcohol, PAHs and derivatives, and substituted phenolic compounds and derivatives which have been reported as environmental estrogens. The existence of estrogenic substances in fossil fuel combustion demands further investigation of their potential adverse effects on human and on the ecosystem. The magnitude of pollution due to global usage of fossil fuels makes it imperative to understand the issue of fossil fuel-derived endocrine activities and the associated health risks, particularly the aggregated risks stemmed from exposure to toxicants of multiple sources. (C) 2003 Elsevier Science Ltd. All rights reserved.
学科主题	Environmental Sciences; Meteorology & Atmospheric Sciences
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Environmental Sciences ; Meteorology & Atmospheric Sciences
研究领域[WOS]	Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences
关键词[WOS]	POLYCYCLIC AROMATIC-HYDROCARBONS ; DISRUPTING CHEMICALS ; LIGHT-DUTY ; ASSAY ; RECEPTOR ; BINDING ; HEALTH ; SCREEN ; BENZANTHRACENE ; GASOLINE
收录类别	SCI
语种	英语
WOS记录号	WOS:000184188500006
公开日期	2010-10-13
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/152342/9682]
专题	水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文
作者单位	1.GSF, Natl Res Ctr Environm & Hlth, Inst Ecol Chem, D-85764 Neuherberg, Germany 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 3.Chem Ind Inst Toxicol, Res Triangle Pk, NC 27709 USA 4.Tech Univ Munich, Lehrstuhl Okol Chem & Umweltanalyt, D-85350 Freising Weihenstephan, Germany
推荐引用方式 GB/T 7714	Wang, JX,Wu, WZ,Henkelmann, B,et al. Presence of estrogenic activity from emission of fossil fuel combustion as detected by a recombinant yeast bioassay[J]. ATMOSPHERIC ENVIRONMENT,2003,37(23):3225-3235.
APA	Wang, JX,Wu, WZ,Henkelmann, B,You, L,Kettrup, A,&Schramm, KW.(2003).Presence of estrogenic activity from emission of fossil fuel combustion as detected by a recombinant yeast bioassay.ATMOSPHERIC ENVIRONMENT,37(23),3225-3235.
MLA	Wang, JX,et al."Presence of estrogenic activity from emission of fossil fuel combustion as detected by a recombinant yeast bioassay".ATMOSPHERIC ENVIRONMENT 37.23(2003):3225-3235.