Synthesis of chiral peptide nucleic acids using fmoc chemistry

	Synthesis of chiral peptide nucleic acids using fmoc chemistry
	Wu Y(武芸) ; Xu JC(徐杰诚)
刊名	Tetrahedron
	2001
卷号	57 期号:38 页码:8107-8113
ISSN号	0040-4020
其他题名	用Fmoc 化学合成手性肽核酸
通讯作者	徐杰诚
英文摘要	A fmoc-based synthesis of chiral PNAs is described. Chiral monomer backbones were efficiently prepared by reductive amination of N-fmoc-protected L,D-alaninals with glycine esters and the subsequent acylation of free amines with thymine-1-ylacetic acid. The dimer derivative of L-amino acid was prepared in solution. Finally, a chiral decamer was obtained by a solid phase strategy using a succinyl-linked support.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/S0040-4020(01)00789-X
语种	英语
WOS记录号	WOS:000171210700012
公开日期	2013-03-04
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/22640]
专题	上海有机化学研究所_上海有机化学研究所
推荐引用方式 GB/T 7714	Wu Y,Xu JC. Synthesis of chiral peptide nucleic acids using fmoc chemistry[J]. Tetrahedron,2001,57(38):8107-8113.
APA	武芸,&徐杰诚.(2001).Synthesis of chiral peptide nucleic acids using fmoc chemistry.Tetrahedron,57(38),8107-8113.
MLA	武芸,et al."Synthesis of chiral peptide nucleic acids using fmoc chemistry".Tetrahedron 57.38(2001):8107-8113.