Analytical and semipreparative resolution of enatiomers of albendazole sulfoxide by HPLC on amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phases

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Analytical and semipreparative resolution of enatiomers of albendazole sulfoxide by HPLC on amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phases
	Shi YP(师彦平)
刊名	Journal of Biochemical and Biophysical Methods
	2005
卷号	62 页码:69-79
关键词	Enantioseparation Polysaccharide carbamate phase Semipreparative HPLC Optical rotation Circular dichroism Albendazole sulfoxide
ISSN号	0165-022X
通讯作者	翟宗德
中文摘要	Broad spectrum anthelmintic agent—albendazole sulfoxide (ABZSO) have been separated and semiprepared on amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phases by HPLC using mobile phases contained with n-hexane and different alcohols. For analytical separation the influence of the nature and content of alcoholic modifiers on separation were systemically studied. Then, the analytical methods were scaled up to semipreparative loading to obtain small quantities (about 1 g) of both ABZSO enantiomers. Especially, different loading amounts were investigated for their effect on various parameters of semipreparative HPLC. In addition, optical rotation and circular dichroism (CD) of both ABZSO enantiomers collected were determined and single enantiomers were found stable in configuration for 1 year.
学科主题	分析化学 ; 药物化学
收录类别	SCI
资助信息	the ministry of science and technology of China under “Basic Study and Prompt Support Program” (No. [2001] 51);the Chinese Academy of Sciences under a “Hundreds of Talents Program”
语种	英语
WOS记录号	WOS:000226922700007
公开日期	2013-03-01
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/2496]
专题	兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
推荐引用方式 GB/T 7714	Shi YP. Analytical and semipreparative resolution of enatiomers of albendazole sulfoxide by HPLC on amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phases[J]. Journal of Biochemical and Biophysical Methods,2005,62:69-79.
APA	师彦平.(2005).Analytical and semipreparative resolution of enatiomers of albendazole sulfoxide by HPLC on amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phases.Journal of Biochemical and Biophysical Methods,62,69-79.
MLA	师彦平."Analytical and semipreparative resolution of enatiomers of albendazole sulfoxide by HPLC on amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phases".Journal of Biochemical and Biophysical Methods 62(2005):69-79.