Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins

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	Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins
	Wang YB(王一兵) ; Zhang YC(张一纯) ; Zhu ZY(朱自严) ; Zhu SL(朱石磊) ; Li YX(李英霞) ; Li M(李明) ; Yu B(俞飚)
刊名	Bioorg. Med. Chem.
	2007
卷号	15 期号:7 页码:2528-2532
ISSN号	0968-0896
其他题名	甾体皂甙的结构，溶血活性以及细胞毒性之间相互关系的研究
通讯作者	俞飚
英文摘要	The hemolytic activity of a collection of 63 steroid saponins was determined. The correlations between these structures and their hemolytic and cytotoxic activities are discussed. It has been demonstrated that the hemolytic activity of steroid saponins is highly dependent on their structures, that is, the sugar length, the sugar linkage, the substitutes on the sugar, as well as the aglycone. It has also been disclosed that the hemolytic activity and cytotoxicity of steroid saponins are not correlated. These results suggest that steroid saponins execute hemolysis and cytotoxic activity in different mechanisms, and encourage to develop steroid saponins into potent antitumor agents devoid of the detrimental effect of hemolysis. (c) 2007 Elsevier Ltd. All rights reserved.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.bmc.2007.01.058
语种	英语
WOS记录号	WOS:000245620200003
公开日期	2013-02-25
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/19057]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Wang YB,Zhang YC,Zhu ZY,et al. Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins[J]. Bioorg. Med. Chem.,2007,15(7):2528-2532.
APA	王一兵.,张一纯.,朱自严.,朱石磊.,李英霞.,...&俞飚.(2007).Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins.Bioorg. Med. Chem.,15(7),2528-2532.
MLA	王一兵,et al."Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins".Bioorg. Med. Chem. 15.7(2007):2528-2532.