Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants

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	Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants
	T. C. Ma ; P. Wan ; Y. Y. Cui ; G. R. Zhang ; J. Q. Li ; J. H. Liu ; Y. B. Ren ; K. Yang ; L. Lu
刊名	Journal of Materials Science & Technology
	2012
卷号	28 期号:7 页码:647-653
关键词	High nitrogen stainless steel Cytoxicity evaluation Osteoblasts Bone Surface energy partially-stabilized zirconia in-vitro surface-roughness adhesion wettability adsorption corrosion bone
ISSN号	1005-0302
中文摘要	Cytocompatibility of high nitrogen nickel-free stainless steel (HNS) with different nitrogen content was evaluated and compared with a conventional austenitic stainless steel 317L. The MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) was performed on MG63 osteoblasts to assess the cytotoxicity. The expression of selected marker typical of differentiated osteoblasts, such as alkaline phosphatase activity (AKP), was also monitored in MG63 cells cultured on the tested materials. As a result, HNS had higher cell growth than 317L; meanwhile the cytocompatibility was increased with increasing nitrogen content. Furthermore, HNS enhanced osteoblasts differentiation, as confirmed by AKP activity. Overall these facts indicated that HNS had higher cytocompatibility than 317L and the nitrogen content contributed to the higher cytocompatibility of HNS. The influence of nitrogen on surface energy further explained the cytocompatibility of HNS.
原文出处	://WOS:000308570200011
公开日期	2013-02-05
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/60155]
专题	金属研究所_中国科学院金属研究所
推荐引用方式 GB/T 7714	T. C. Ma,P. Wan,Y. Y. Cui,et al. Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants[J]. Journal of Materials Science & Technology,2012,28(7):647-653.
APA	T. C. Ma.,P. Wan.,Y. Y. Cui.,G. R. Zhang.,J. Q. Li.,...&L. Lu.(2012).Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants.Journal of Materials Science & Technology,28(7),647-653.
MLA	T. C. Ma,et al."Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants".Journal of Materials Science & Technology 28.7(2012):647-653.