An efficient and tunable route to AG7088, a rhinovirus protease inhibitor

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	An efficient and tunable route to AG7088, a rhinovirus protease inhibitor
	Ma DW(马大为) ; Xie WQ(谢卫青) ; Zou B(邹斌) ; LEI QIONG ; Pei DQ(裴端卿)
刊名	Tetrahedron Lett.
	2004
卷号	45 期号:43 页码:8103-8105
ISSN号	0040-4039
其他题名	An efficient and tunable route to AG7088, a rhinovirus protease inhibitor
通讯作者	马大为
英文摘要	Aldol reaction of N,N-dibenzyl valinal with propiolic acid ethyl ester derived lithium reagent provides anti-aminoalcohol 8 and syn-aminoalcohol 9, which are converted into the lactone 6 via two different routes. Alkylation of 6 followed by lactone ring opening afford the acid 2a, which is coupled with the amine 3 and 5-methylisoxazole-3-carboxylate acid 1, respectively, to deliver AG7088. (C) 2004 Elsevier Ltd. All rights reserved
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.tetlet.2004.08.179
语种	英语
WOS记录号	WOS:000224447600031
公开日期	2013-02-19
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/15475]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Ma DW,Xie WQ,Zou B,et al. An efficient and tunable route to AG7088, a rhinovirus protease inhibitor[J]. Tetrahedron Lett.,2004,45(43):8103-8105.
APA	马大为,谢卫青,邹斌,LEI QIONG,&裴端卿.(2004).An efficient and tunable route to AG7088, a rhinovirus protease inhibitor.Tetrahedron Lett.,45(43),8103-8105.
MLA	马大为,et al."An efficient and tunable route to AG7088, a rhinovirus protease inhibitor".Tetrahedron Lett. 45.43(2004):8103-8105.