Comprehensive Characterization of the RNA Editomes in Cancer Development and Progression | |
Luo, Haitao1,2; Fang, Shuangsang1,2; Sun, Liang1; Liu, Zhiyong3; Zhao, Yi1 | |
刊名 | FRONTIERS IN GENETICS |
2018-01-17 | |
卷号 | 8页码:8 |
关键词 | post-transcriptional regulation RNA editome tumorigenesis metastasis transcriptome |
ISSN号 | 1664-8021 |
DOI | 10.3389/fgene.2017.00230 |
英文摘要 | RNA editing is a post-transcriptional event that leads to transcriptome diversity and has been shown to play important roles in tumorigenesis. However, dynamical changes and the functional significance of editing events during different cancer stages have not yet been characterized systematically. In this paper, we describe a comprehensive study of the RNA editome of four samples from different cancer stages for the same patient based on analysis of both whole-genome and transcriptome sequencing data. We identified 35,225 and 33,784 RNA editing events for poly(A)(+) and poly(A)(-) RNA sequencing data respectively in all four samples and show that 93 and 90% correspond to cancer stage-specific editing events. We also found that half of editing sites in 3' UTR of coding genes were microRNA targets and most of the sites in the coding regions could lead to non-synonymous amino acid changes. Functional analysis of genes which suffered damaging non-synonymous editing events in each cancer stage show the gradual expansion of cancer related pathways accompanied by an increasing malignant grade of the samples. Our study, for the first time to our knowledge, comprehensively profiled and compared the editomes across the different cancer stages and revealed the functional impacts of RNA editing events during cancer development and progression. |
资助项目 | National Natural Science Foundation of China[3140111] ; National Natural Science Foundation of China[31371320] ; National Natural Science Foundation of China[61472397] ; National Natural Science Foundation of China[31501066] |
WOS研究方向 | Genetics & Heredity |
语种 | 英语 |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:000422693700001 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.204/handle/2XEOYT63/6249] |
专题 | 中国科学院计算技术研究所期刊论文_英文 |
通讯作者 | Luo, Haitao; Zhao, Yi |
作者单位 | 1.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Adv Comp Res Ctr, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Luo, Haitao,Fang, Shuangsang,Sun, Liang,et al. Comprehensive Characterization of the RNA Editomes in Cancer Development and Progression[J]. FRONTIERS IN GENETICS,2018,8:8. |
APA | Luo, Haitao,Fang, Shuangsang,Sun, Liang,Liu, Zhiyong,&Zhao, Yi.(2018).Comprehensive Characterization of the RNA Editomes in Cancer Development and Progression.FRONTIERS IN GENETICS,8,8. |
MLA | Luo, Haitao,et al."Comprehensive Characterization of the RNA Editomes in Cancer Development and Progression".FRONTIERS IN GENETICS 8(2018):8. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论