Conformational sensitivity of surface selection rules for quantitative Raman identification of small molecules in biofluids

doi:10.1039/c8nr04710c

CORC > 合肥物质科学研究院 > 中国科学院合肥物质科学研究院 > 中国科学院核能安全技术研究所

	Conformational sensitivity of surface selection rules for quantitative Raman identification of small molecules in biofluids
	Li, Lei4 ; Wang, Chao 5; Yang, Lina 4; Su, Mengke 4; Yu, Fanfan 4; Tian, Li 4; Liu, Honglin 1,2,3,4
刊名	NANOSCALE
	2018-08-07
卷号	10 期号:29 页码:14342-14351
ISSN号	2040-3364
DOI	10.1039/c8nr04710c
通讯作者	Liu, Honglin(liuhonglin@mail.ustc.edu.cn)
英文摘要	Biofluid analysis by surface-enhanced Raman scattering (SERS) is usually hindered by nonspecific interferences. It is challenging to drive targeted molecules towards sensitive areas with specific capture and quantitative recognition in complex biofluids. Herein, a highly specific and quantitative SERS analyzer for small molecule dopamine (DA) in serum is demonstrated on a portable Raman device by virtue of a transducer of mercaptophenylboronic acid (MPBA) and a site-directed decoration of plasmonic Ag dendrites on a superhydrophobic surface. Theoretical simulations of molecular vibrations and charge distributions demonstrate the predomination of Raman surface selection rules in molecular reorientation upon the binding of DA. This recognition event is translated into ratiometric changes in the spectral profile which evidences excellent capability on SERS quantitation. The rules can well distinguish DA from its common interferents including fructose, glucose, sucrose and ascorbic acid which all generate weak but completely opposite spectral changes. Moreover, benefitting from the wettability difference, the target DA in diluted serum can be specifically enriched on a transducer-capped Ag surface, and the adsorption of other interferences is resisted by superhydrophobic features. It paves a new way for labelling a single SERS tag to simultaneously realize the identification and quantification of small molecules in complex biological media.
资助项目	National Natural Science Foundation of China[U1632116] ; National Natural Science Foundation of China[11705044] ; National Natural Science Foundation of China[11604341] ; Fundamental Research Funds for the Central Universities ; Key Research and Development Project of Anhui Province[1704a07020067] ; Key Projects of Applied Basic Research of Hunan Province[2016JC2065] ; China Postdoctoral Science Foundation[2015M582322] ; China Postdoctoral Science Foundation[2016T90748] ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University
WOS关键词	BORONIC ACID ; SUPERHYDROPHOBIC SURFACES ; GOLD NANOPARTICLES ; SERS DETECTION ; DOPAMINE ; SPECTROSCOPY ; SCATTERING ; SILVER ; COPPER ; RING
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000443633600059
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Key Research and Development Project of Anhui Province ; Key Research and Development Project of Anhui Province ; Key Research and Development Project of Anhui Province ; Key Research and Development Project of Anhui Province ; Key Research and Development Project of Anhui Province ; Key Research and Development Project of Anhui Province ; Key Research and Development Project of Anhui Province ; 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Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; 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China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; 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Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University ; Open Project of State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/38597]
专题	合肥物质科学研究院_中国科学院核能安全技术研究所
通讯作者	Liu, Honglin
作者单位	1.Minist Educ, Engn Res Ctr Bioproc, Hefei 230009, Anhui, Peoples R China 2.Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Mol Sci & Biomed Lab, Coll Chem & Chem Engn,Coll Life Sci, Changsha 410082, Hunan, Peoples R China 3.Hunan Univ, Aptamer Engn Ctr Hunan Prov, Changsha 410082, Hunan, Peoples R China 4.Hefei Univ Technol, Coll Food Sci & Engn, Hefei 230009, Anhui, Peoples R China 5.Chinese Acad Sci, Inst Nucl Energy Safety Technol, Key Lab Neutron & Radiat Safety, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Li, Lei,Wang, Chao,Yang, Lina,et al. Conformational sensitivity of surface selection rules for quantitative Raman identification of small molecules in biofluids[J]. NANOSCALE,2018,10(29):14342-14351.
APA	Li, Lei.,Wang, Chao.,Yang, Lina.,Su, Mengke.,Yu, Fanfan.,...&Liu, Honglin.(2018).Conformational sensitivity of surface selection rules for quantitative Raman identification of small molecules in biofluids.NANOSCALE,10(29),14342-14351.
MLA	Li, Lei,et al."Conformational sensitivity of surface selection rules for quantitative Raman identification of small molecules in biofluids".NANOSCALE 10.29(2018):14342-14351.