Chemical transformations of mackinazolinone and its derivatives

CORC > 新疆理化技术研究所 > 中国科学院新疆理化技术研究所 > 省部共建新疆特有药用资源利用重点实验室

	Chemical transformations of mackinazolinone and its derivatives
	Nasrullaev A. O.; Turdibaev Zh E.; Elmuradov B. Zh; Yili A.; Aisa H. A.; Shakhidoyatov Kh M.
刊名	CHEMISTRY OF NATURAL COMPOUNDS
	2012
卷号	48 期号:4 页码:638-642
关键词	mackinazolinone mackinazolinthione nucleophilic substitution electrophilic addition
ISSN号	0009-3130
英文摘要	The thioanalog of mackinazolinone (2,3,4,10-tetrahydro-1 H-pyrido2,1-bquinazolin-10-one) was synthesized for the first time by reacting it with P2S5. The thioanalog was reacted with aromatic aldehydes and Vilsmeier- Haack reagent (DMF + POCl3) to produce 4-arylidene- and -hydroxymethylidenemackinazolinthiones, respectively. The reactions of 4-hydroxymethylidenemackinazolinone with isomeric aminophenols and aminobenzoic acids and of hydroxymethylidenemackinazolinthione with thionylchloride were studied. Subsequent reaction of the obtained 4-chloromethylidene derivative with sodium hydroselenide was synthesized a new Se-containing derivative of mackinazolinone. It was shown that 4-formylmackinazolinthione existed in the enol form whereas 4-formylmackinazolinone existed as the enaminoaldehyde tautomer.
学科主题	Pharmacology & Pharmacy ; Chemistry
收录类别	SCI
WOS记录号	WOS:000309471600030
公开日期	2012-11-29
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/1610]
专题	新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室新疆理化技术研究所_资源化学研究室
作者单位	Uzbek Acad Sci, S Yu Yunusov Inst Chem Plant Subst, Tashkent 700135, Uzbekistan;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China
推荐引用方式 GB/T 7714	Nasrullaev A. O.,Turdibaev Zh E.,Elmuradov B. Zh,et al. Chemical transformations of mackinazolinone and its derivatives[J]. CHEMISTRY OF NATURAL COMPOUNDS,2012,48(4):638-642.
APA	Nasrullaev A. O.,Turdibaev Zh E.,Elmuradov B. Zh,Yili A.,Aisa H. A.,&Shakhidoyatov Kh M..(2012).Chemical transformations of mackinazolinone and its derivatives.CHEMISTRY OF NATURAL COMPOUNDS,48(4),638-642.
MLA	Nasrullaev A. O.,et al."Chemical transformations of mackinazolinone and its derivatives".CHEMISTRY OF NATURAL COMPOUNDS 48.4(2012):638-642.