Directional guidance of neuronal migration in the olfactory system by the protein Slit

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Directional guidance of neuronal migration in the olfactory system by the protein Slit
	Wu, W ; Wong, K ; Chen, JH ; Jiang, ZH ; Dupuls, S ; Wu, JY ; Rao, Y
刊名	NATURE
	1999
卷号	400 期号:6742 页码:331-336
关键词	SUBVENTRICULAR ZONE CELLS NEURAL CREST MIGRATION FETAL MONKEY NEOCORTEX POLYSIALIC ACID NERVOUS-SYSTEM AXON GUIDANCE GENE ENCODES C-ELEGANS GLIA PRECURSORS
ISSN号	0028-0836
通讯作者	Wu, JY (reprint author), Washington Univ, Sch Med, Dept Anat & Neurobiol, Box 8108,660 S Euclid Ave, St Louis, MO 63110 USA,
英文摘要	Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration.
学科主题	Science & Technology - Other Topics
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2100]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Wu, W,Wong, K,Chen, JH,et al. Directional guidance of neuronal migration in the olfactory system by the protein Slit[J]. NATURE,1999,400(6742):331-336.
APA	Wu, W.,Wong, K.,Chen, JH.,Jiang, ZH.,Dupuls, S.,...&Rao, Y.(1999).Directional guidance of neuronal migration in the olfactory system by the protein Slit.NATURE,400(6742),331-336.
MLA	Wu, W,et al."Directional guidance of neuronal migration in the olfactory system by the protein Slit".NATURE 400.6742(1999):331-336.