GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons

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	GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons
	Yang, F ; Feng, LY ; Zheng, F ; Johnson, SW ; Du, J ; Shen, LY ; Wu, CP ; Lu, B
刊名	NATURE NEUROSCIENCE
	2001
卷号	4 期号:11 页码:1071-1078
关键词	VENTRAL MESENCEPHALIC NEURONS MICE LACKING GDNF NEUROTROPHIC FACTOR NERVOUS-SYSTEM ELECTROPHYSIOLOGICAL PROPERTIES SYNAPTIC TRANSMISSION TYROSINE KINASE CATION CURRENT IN-VIVO RECEPTOR
ISSN号	1097-6256
通讯作者	Lu, B (reprint author), NICHHD, Unit Synapse Dev & Plast, LCSN, NIH, Bethesda, MD 20892 USA,
英文摘要	Glial cell line-derived neurotrophic factor (GDNF) prevents lesion-induced death of midbrain dopaminergic neurons, but its function in normal brain remains uncertain. Here we show that GDNF acutely and reversibly potentiated the excitability of cultured midbrain neurons by inhibiting transient A-type K+ channels. The effects of GDNF were limited to large, tyrosine hydroxylase (TH)positive dopaminergic neurons, and were mediated by mitogen associated protein (MAP) kinase. Application of GDNF also elicited a MAP kinase-dependent enhancement of the excitability in dopaminergic neurons in midbrain slice. These results demonstrate an acute regulation of GDNF on ion channels and its underlying signaling mechanism, and reveal an unexpected role of GDNF in normal midbrain dopaminergic neurons.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2069]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Yang, F,Feng, LY,Zheng, F,et al. GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons[J]. NATURE NEUROSCIENCE,2001,4(11):1071-1078.
APA	Yang, F.,Feng, LY.,Zheng, F.,Johnson, SW.,Du, J.,...&Lu, B.(2001).GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons.NATURE NEUROSCIENCE,4(11),1071-1078.
MLA	Yang, F,et al."GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons".NATURE NEUROSCIENCE 4.11(2001):1071-1078.