Taurine activates strychnine-sensitive glycine receptors in neurons of the rat inferior colliculus

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	Taurine activates strychnine-sensitive glycine receptors in neurons of the rat inferior colliculus
	Xu, H ; Zhou, KQ ; Huang, YN ; Chen, L ; Xu, TL(徐天乐）
刊名	BRAIN RESEARCH
	2004
卷号	1021 期号:2 页码:232-240
关键词	taurine inferior colliculus whole cell patch clamp glycine receptor GABA(A) receptor strychnine bicuculline rat SUBSTANTIA-NIGRA NEURONS ROOT GANGLION NEURONS NEUROTRANSMITTER AMINO-ACIDS EPILEPSY-PRONE RAT INTRACELLULAR CHLORIDE AUDITORY-CORTEX SOUND DURATION OLFACTORY-BULB GABA INHIBITION
ISSN号	0006-8993
通讯作者	Chen, L (reprint author), Univ Sci & Technol China, Dept Neurobiol & Biophys, Sch Life Sci, POB 4, Hefei 230027, Peoples R China,linchen@ustc.edu.cn
英文摘要	Taurine (Tau) is one of the most abundant free amino acids in the mammalian central nervous system. Whether the neurotransmission of the central auditory system is regulated or modulated by Tau is not clear. In the present study, we investigated the electrophysiological and pharmacological properties of Tau-activated currents in acutely dissociated neurons of the rat inferior colliculus (IC) using whole cell patch clamp recordings. At a holding potential of -60 mV and under a condition of chloride equilibrium potential near 0 mV, Tau activated an inward current and its half-maximal activation concentration was equal to 0.37 mM. The measured reversal potential of Tau-activated currents was close to theoretical chloride equilibrium potential. The currents evoked by Tau at both low (1 mM) and high (10 mM) concentrations were almost completely inhibited by strychnine, a glycine receptor antagonist. The Tau-activated current, however, was not affected by bicuculline, a GABAA receptor antagonist. Tau at increased concentrations progressively reduced the current response to subsequent glycine application. At saturated concentrations, Tau-activated current and glycine-activated current were mutually cross-desensitized by each other. These findings indicate that Tau activates glycine receptors in neurons of the rat IC and thus may have a functional role in regulating or modulating the neurotransmission of the central auditory system in mammals. (C) 2004 Elsevier B.V. All rights reserved.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1943]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Xu, H,Zhou, KQ,Huang, YN,et al. Taurine activates strychnine-sensitive glycine receptors in neurons of the rat inferior colliculus[J]. BRAIN RESEARCH,2004,1021(2):232-240.
APA	Xu, H,Zhou, KQ,Huang, YN,Chen, L,&Xu, TL.(2004).Taurine activates strychnine-sensitive glycine receptors in neurons of the rat inferior colliculus.BRAIN RESEARCH,1021(2),232-240.
MLA	Xu, H,et al."Taurine activates strychnine-sensitive glycine receptors in neurons of the rat inferior colliculus".BRAIN RESEARCH 1021.2(2004):232-240.