Taurine acts as a glycine receptor agonist in slices of rat inferior colliculus

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	Taurine acts as a glycine receptor agonist in slices of rat inferior colliculus
	Wang, Wei
刊名	HEARING RESEARCH
	2006
卷号	220 期号:40910 页码:95-105
关键词	taurine glycine receptor central nucleus of inferior colliculus brain slice rat whole-cell patch-clamp NEUROTRANSMITTER AMINO-ACIDS FOCAL CEREBRAL-ISCHEMIA CENTRAL-NERVOUS-SYSTEM GABA-A RECEPTOR OLFACTORY-BULB ELECTRICAL-STIMULATION DEVELOPMENTAL-CHANGES GABAERGIC INHIBITION CALCIUM HOMEOSTASIS AUDITORY-SYSTEM
ISSN号	0378-5955
通讯作者	Xu, TL (reprint author), Univ Sci & Technol China, Sch Life Sci, Audit Res Lab, Hefei 230027, Peoples R China,tlxu@ion.ac.cn
英文摘要	Taurine is an important endogenous amino acid for neural development and for many physiological functions,but little is known about its functional role in the central auditory system. We investigated in young rats (P10-P14) the effects of taurine on the neuronal responses and synaptic transmissions in the central nucleus of the inferior colliculus (ICC) with a brain slice preparation and with whole-cell patch-clamp recordings. Perfusion of taurine at I mM reliably evoked a current across the membrane and decreased the input resistance in neurons of the ICC. Taurine also depressed the spontaneous and current-evoked firing of ICC neurons. All these effects were reversible after washout and could be blocked by 3 mu M strychnine, an antagonist of glycine receptors, but not by 10 mu M bicuculline, an antagonist of GABA(A) receptors. When the inhibitory receptors were not pharmacologically blocked, taurine reversibly reduced the postsynaptic currents/potentials evoked by electrically stimulating the commissure of the inferior colliculus or the ipsilateral lateral lemniscus. The results demonstrate that taurine reduces the neuronal excitability and depresses the synaptic transmission in the ICC by activating glycine-gated chloride channels. Our findings suggest that taurine acts as a ligand of glycine receptors in the ICC and can be involved in the information processing of the central auditory system similarly like the neuro transmitter glycine. (c) 2006 Elsevier B.V. All rights reserved.
学科主题	Audiology & Speech-Language Pathology ; Neurosciences & Neurology ; Otorhinolaryngology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1804]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_视知觉机制研究组
推荐引用方式 GB/T 7714	Wang, Wei. Taurine acts as a glycine receptor agonist in slices of rat inferior colliculus[J]. HEARING RESEARCH,2006,220(40910):95-105.
APA	Wang, Wei.(2006).Taurine acts as a glycine receptor agonist in slices of rat inferior colliculus.HEARING RESEARCH,220(40910),95-105.
MLA	Wang, Wei."Taurine acts as a glycine receptor agonist in slices of rat inferior colliculus".HEARING RESEARCH 220.40910(2006):95-105.