Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators

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	Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators
	Xu, Tian-Le(徐天乐) ; Xiong, Zhi-Gang
刊名	CURRENT MEDICINAL CHEMISTRY
	2007
卷号	14 期号:16 页码:1753-1763
关键词	acid-sensing ion channel acidosis neuron modulation ROOT GANGLION NEURONS PROTON-GATED CHANNELS TARANTULA TOXIN PSALMOTOXIN-1 EXPERIMENTAL TISSUE ACIDOSIS EPITHELIAL SODIUM-CHANNEL MOUSE CORTICAL-NEURONS BRAIN NA+ CHANNEL PROTEIN-KINASE-C SENSORY NEURONS HIPPOCAMPAL-NEURONS
ISSN号	0929-8673
通讯作者	Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
英文摘要	Changes of extracellular pH values can have profound effects on neuronal function. For example, the low pH (also called acidosis) generated in brain ischemia causes acute neuronal injury. For years the receptors that detect pH variations surrounding neurons and their physiological/pathological importance remain uncertain, The recent finding that acidosis activates a distinct family of membrane ion channels, the acid-sensing ion channels (ASICs) in both peripheral and central neurons has dramatically changed the view of acidosis-associated signaling and provided a new strategy for therapeutic inventions. Although proton is the only known agonist for the activation of ASICs, a variety of extracellular and intracellular signaling molecules can modulate the activities of ASICs and have profound influence on the functions of these channels in both physiological and pathological processes. The goal of this article is therefore to provide a comprehensive review of the modulators of ASICs that adapt ASIC activity to changes of extracellular and intracellular environments.
学科主题	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1794]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Xu, Tian-Le,Xiong, Zhi-Gang. Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators[J]. CURRENT MEDICINAL CHEMISTRY,2007,14(16):1753-1763.
APA	Xu, Tian-Le,&Xiong, Zhi-Gang.(2007).Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators.CURRENT MEDICINAL CHEMISTRY,14(16),1753-1763.
MLA	Xu, Tian-Le,et al."Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators".CURRENT MEDICINAL CHEMISTRY 14.16(2007):1753-1763.