Semaphorin-3A guides radial migration of cortical neurons during development

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	Semaphorin-3A guides radial migration of cortical neurons during development
	Chen, Gang ; Sima, Jian ; Jin, Ming ; Wang, Kai-yu ; Xue, Xiao-jing ; Zheng, Wang ; Ding, Yu-qiang ; Yuan, Xiao-bing
刊名	NATURE NEUROSCIENCE
	2008
卷号	11 期号:1 页码:36-44
关键词	MESSENGER-RNA EXPRESSION CENTRAL-NERVOUS-SYSTEM CEREBRAL-CORTEX GROWTH CONES RECEPTOR NEUROPILIN PROTEIN REELIN BRAIN NEOCORTEX
ISSN号	1097-6256
通讯作者	Yuan, XB (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yuanxb@ion.ac.cn
英文摘要	Postmitotic neurons in the developing cortex migrate along radial glial fibers to their proper location in the cortical plate and form the layered structure. Here we report that the radial migration of rat layer II/III cortical neurons requires guidance by the extracellular diffusible factor Semaphorin-3A (Sema3A). This factor is expressed in a descending gradient across the cortical layers, whereas its receptor neuropilin-1 (NP1) is highly expressed in migrating neurons. Downregulation or conditional knockout of NP1 in newborn cortical neurons impedes their radial migration by disrupting their radial orientation during migration without altering their cell fate. Studies in cultured cortical slices further show that the endogenous gradient of Sema3A is required for the proper migration of newborn neurons. In addition, transwell chemotaxis assays show that isolated newborn neurons are attracted by Sema3A. Thus, Sema3A may function as a chemoattractive guidance signal for the radial migration of newborn cortical neurons toward upper layers.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1743]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Chen, Gang,Sima, Jian,Jin, Ming,et al. Semaphorin-3A guides radial migration of cortical neurons during development[J]. NATURE NEUROSCIENCE,2008,11(1):36-44.
APA	Chen, Gang.,Sima, Jian.,Jin, Ming.,Wang, Kai-yu.,Xue, Xiao-jing.,...&Yuan, Xiao-bing.(2008).Semaphorin-3A guides radial migration of cortical neurons during development.NATURE NEUROSCIENCE,11(1),36-44.
MLA	Chen, Gang,et al."Semaphorin-3A guides radial migration of cortical neurons during development".NATURE NEUROSCIENCE 11.1(2008):36-44.