Guidance of cortical radial migration by gradient of diffusible factors

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Guidance of cortical radial migration by gradient of diffusible factors
	Zheng, Wang ; Yuan, Xiaobing
刊名	CELL ADHESION & MIGRATION
	2008
卷号	2 期号:1 页码:48-50
关键词	radial migration cortex guidance semaphorin diffusible factors growth cone
ISSN号	1933-6918
通讯作者	Yuan, XB (reprint author), Chinese Acad Sci, Inst Neurosci, SIBS, Lab Neural Circuit Dev, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yuanxb@ion.ac.cn
英文摘要	During the development of cerebral cortex, newborn pyramidal neurons originated from the ventricle wall migrate outwardly to the superficial layer of cortex under the guidance of radial glial filaments. Whether this radial migration of young neurons is guided by gradient of diffusible factors or simply driven by a mass action of newly generated neurons at the ventricular zone is entirely unknown, a potential guidance mechanism that has long been overlooked. Our recent study showed that a guidance molecule semaphorin-3A, which is expressed in descending gradient across cortical layers, may serve as a chemoattractive guidance signal for radial migration of newborn cortical neurons toward upper layers. We hypothesize the existence of four groups of extracellular factors that can guide the radial migration of young neurons: (1) attractive factors expressing in superficial layers of cortex, (2) repulsive factors enriched in the ventricular zone, (3) pro-migratory factors uniformly expressed in all cortical layers and (4) stop signals locally expressed in the outmost layer of cortex.
学科主题	Cell Biology
收录类别	SCI
资助信息	National Natural Science Foundation of China[30300103]; Shanghai government[06QH14017]
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1742]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zheng, Wang,Yuan, Xiaobing. Guidance of cortical radial migration by gradient of diffusible factors[J]. CELL ADHESION & MIGRATION,2008,2(1):48-50.
APA	Zheng, Wang,&Yuan, Xiaobing.(2008).Guidance of cortical radial migration by gradient of diffusible factors.CELL ADHESION & MIGRATION,2(1),48-50.
MLA	Zheng, Wang,et al."Guidance of cortical radial migration by gradient of diffusible factors".CELL ADHESION & MIGRATION 2.1(2008):48-50.