amnesiac regulates sleep onset and maintenance in Drosophila melanogaster

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	amnesiac regulates sleep onset and maintenance in Drosophila melanogaster
	Liu, Weijie ; Guo, Fang ; Lu, Beika ; Guo, Aike
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2008
卷号	372 期号:4 页码:798-803
关键词	aging amnesiac Drosophila sleep fragmentation sleep onset MUSHROOM BODIES GENE-PRODUCT MEMORY MODULATION REST AGE MUTANTS WAKING BRAIN
ISSN号	0006-291X
通讯作者	Guo, AK (reprint author), Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, 15 Datun Rd, Beijing 100101, Peoples R China,akguo@ion.ac.cn
英文摘要	The adenylate cyclase/cAMP signaling pathway and adult mushroom bodies (MBs) have been shown to play an important role in sleep regulation in Drosophila. The amnesiac (amn) gene, encodes a neuropeptide that is homologous with vertebrate pituitary adenylate cyclase-activating peptide (PACAP), is expressed in dorsal paired medial (DPM) neurons and is required for the middle-term memory (MTM) in flies. However, the role of amn on regulation of sleep is as yet unknown. Here we provide evidence that amn plays a Major role on sleep maintenance and onset in Drosophila. Flies with the amnesiac allele, loss-of-function amn(x8) mutation, showed a fragmented sleep pattern and short sleep latency. Moreover, homeostatic regulation was disrupted in amn(x8) mutants after sleep deprivation. Sleep maintenance was also influenced by disruption of neurotransmission in DPM neurons with increased sleep bout number and decreased sleep bout length. Furthermore, age-related sleep fragmentation and initiation were inhibited in amnx8 mutant flies. These data suggest that amn is required in initiation and maintenance of sleep. (c) 2008 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Biophysics
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1703]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Liu, Weijie,Guo, Fang,Lu, Beika,et al. amnesiac regulates sleep onset and maintenance in Drosophila melanogaster[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,372(4):798-803.
APA	Liu, Weijie,Guo, Fang,Lu, Beika,&Guo, Aike.(2008).amnesiac regulates sleep onset and maintenance in Drosophila melanogaster.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,372(4),798-803.
MLA	Liu, Weijie,et al."amnesiac regulates sleep onset and maintenance in Drosophila melanogaster".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 372.4(2008):798-803.