EXPRESSION AND REGULATED NUCLEAR TRANSPORT OF TRANSDUCERS OF REGULATED CREB 1 IN RETINAL GANGLION CELLS (Retracted article. See vol. 169, pg. 950, 2010)

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	EXPRESSION AND REGULATED NUCLEAR TRANSPORT OF TRANSDUCERS OF REGULATED CREB 1 IN RETINAL GANGLION CELLS (Retracted article. See vol. 169, pg. 950, 2010)
	Deng, J. ; Zhang, X. -L. ; Wang, J. -W. ; Teng, L. -L. ; Ge, J. ; Takeiviori, H. ; Xiong, Z. -Q. ; Zhou, Y.
刊名	NEUROSCIENCE
	2009
卷号	159 期号:3 页码:1023-1031
关键词	TORC1 retinal ganglion cells Ca(2+) retinal ischemic injury ELEMENT-BINDING PROTEIN SENSITIVE COINCIDENCE DETECTOR ISCHEMIA-REPERFUSION INJURY MEDIATED GENE-EXPRESSION REGENERATIVE CAPACITY COACTIVATOR TORC2 IN-VIVO PHOSPHORYLATION ACTIVATION TRANSCRIPTION
ISSN号	0306-4522
通讯作者	Zhang, XL (reprint author), Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China,zhangxl2@mail.sysu.edu.cn ; yzhou@ion.ac.cn
英文摘要	Calcium- and cAMP-dependent activation of CREB and transcription of cAMP-responsive element (CRE)-target genes play critical roles in various physiological and pathological conditions. TORCs (transducers of regulated CREB) represent a new family of conserved CREB coactivators that function as intracellular calcium- and cAMP-sensitive coincidence detectors, controlling the kinetics of CRE-mediated responses and long-term potentiation of synaptic transmission. Here we examined the expression and activity-dependent translocaition of TORCs in adult retinal ganglion cells (RGCs), the primary target of acute retinal ischemic injury as well as chronic: retinal degenerative diseases. We found that both mRNAs of TORC1 and TORC2, but not TORC3, were enriched in adult rat retina. Comparing with TORC2, TORC1 protein was highly and selectively expressed in RGCs. At resting condition, TORC1 protein was localized in the cytoplasm but not nucleus of RGCs. Activation of N-methyl-D-aspartate (NMDA) receptors by intravitreous injection of NMDA or increase of cAMP signaling by administration of forskolin triggered nuclear accumulation of TORC1. Furthermore, transient retinal ischemic injury resulted in peri-nuclear and nuclear accumulation of TORC1 as well as transcription of BDNF in RGCs. Our results demonstrate that TORC1 is enriched in RGCs and its subcellular location could be regulated by Ca(2+) and cAMP, suggesting that manipulation of TORC1 activity may promote survival of IRGCs in some optic disease conditions. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	Project of Science and Technology of Guangdong Province[2008B060600061]; Guangdong Natural Science Foundation Key Project[7117359]; National Natural Science Foundation of China[30872831]; State Key Laboratory of Neuroscience, Chinese Academy of Sciences[SKLN-2008A03]; National Basic Research Project[2007CB512200]; National Nature Science Foundation of China[30800318]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1667]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Deng, J.,Zhang, X. -L.,Wang, J. -W.,et al. EXPRESSION AND REGULATED NUCLEAR TRANSPORT OF TRANSDUCERS OF REGULATED CREB 1 IN RETINAL GANGLION CELLS (Retracted article. See vol. 169, pg. 950, 2010)[J]. NEUROSCIENCE,2009,159(3):1023-1031.
APA	Deng, J..,Zhang, X. -L..,Wang, J. -W..,Teng, L. -L..,Ge, J..,...&Zhou, Y..(2009).EXPRESSION AND REGULATED NUCLEAR TRANSPORT OF TRANSDUCERS OF REGULATED CREB 1 IN RETINAL GANGLION CELLS (Retracted article. See vol. 169, pg. 950, 2010).NEUROSCIENCE,159(3),1023-1031.
MLA	Deng, J.,et al."EXPRESSION AND REGULATED NUCLEAR TRANSPORT OF TRANSDUCERS OF REGULATED CREB 1 IN RETINAL GANGLION CELLS (Retracted article. See vol. 169, pg. 950, 2010)".NEUROSCIENCE 159.3(2009):1023-1031.