Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation
	Shu, Yousheng
刊名	NATURE NEUROSCIENCE
	2009
卷号	12 期号:8 页码:996-U61
关键词	NEOCORTICAL PYRAMIDAL NEURONS DEPENDENT SYNAPTIC PLASTICITY SODIUM-CHANNELS ION CHANNELS CELL-TYPE AXON SEGMENT ACTIVATION SPIKES MODEL
ISSN号	1097-6256
通讯作者	Shu, YS (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai, Peoples R China,shu@ion.ac.cn
英文摘要	The distal end of the axon initial segment (AIS) is the preferred site for action potential initiation in cortical pyramidal neurons because of its high Na+ channel density. However, it is not clear why action potentials are not initiated at the proximal AIS, which has a similarly high Na+ channel density. We found that low-threshold Na(v)1.6 and high-threshold Na(v)1.2 channels preferentially accumulate at the distal and proximal AIS, respectively, and have distinct functions in action potential initiation and backpropagation. Patch-clamp recording from the axon cut end of pyramidal neurons in the rat prefrontal cortex revealed a high density of Na+ current and a progressive reduction in the half-activation voltage (up to 14 mV) with increasing distance from the soma at the AIS. Further modeling studies and simultaneous somatic and axonal recordings showed that distal Na(v)1.6 promotes action potential initiation, whereas proximal Na(v)1.2 promotes its backpropagation to the soma.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	973 Program[2006CB806600]; Shanghai Commission of Science and Technology[06DJ14010]; Shanghai Pujiang Program[07PJ14108]; Chinese Academy of Sciences[KSCX2-YW-R-102]; Scientific Research Foundation of the State Human Resource Ministry and the Education Ministry
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1652]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经网络功能研究组
推荐引用方式 GB/T 7714	Shu, Yousheng. Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation[J]. NATURE NEUROSCIENCE,2009,12(8):996-U61.
APA	Shu, Yousheng.(2009).Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation.NATURE NEUROSCIENCE,12(8),996-U61.
MLA	Shu, Yousheng."Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation".NATURE NEUROSCIENCE 12.8(2009):996-U61.